Kinetic modeling to explain the release of medicine from drug delivery systems
M Askarizadeh, N Esfandiari, B Honarvar… - ChemBioEng …, 2023 - Wiley Online Library
Proper medication dissolution must be ensured when developing or manufacturing a new
solid dosage form. Quantitative analyses performed in dissolution or release tests become …
solid dosage form. Quantitative analyses performed in dissolution or release tests become …
Insight into the pivotal role of signaling pathways in psoriasis pathogenesis, potential therapeutic molecules and drug delivery approaches
Y Tomar, S Gorantla, G Singhvi - Drug discovery today, 2023 - Elsevier
Highlights•Psoriasis is a chronic inflammatory skin disorder affecting 125 million people
worldwide.•The intracellular pathways JAK-STAT, PDE4, S1P, A 3 AR and NF-κB have been …
worldwide.•The intracellular pathways JAK-STAT, PDE4, S1P, A 3 AR and NF-κB have been …
Boosting the anticancer activity of sunitinib malate in breast cancer through lipid polymer hybrid nanoparticles approach
In the current study, lipid-polymer hybrid nanoparticles (LPHNPs) fabricated with lipoid-90H
and chitosan, sunitinib malate (SM), an anticancer drug was loaded using lecithin as a …
and chitosan, sunitinib malate (SM), an anticancer drug was loaded using lecithin as a …
Design and evaluation of solid lipid nanoparticles loaded topical gels: repurpose of fluoxetine in diabetic wound healing
The current study aimed to prepare a topical gel containing solid lipid nanoparticles (SLNs)
encapsulating fluoxetine for diabetic wound healing effects. Fluoxetine (FX) was loaded into …
encapsulating fluoxetine for diabetic wound healing effects. Fluoxetine (FX) was loaded into …
Development of chitosan-coated PLGA-based nanoparticles for improved oral olaparib delivery: in vitro characterization, and in vivo pharmacokinetic studies
Olaparib (OLP) is an orally active poly (ADP-ribose) polymerase enzyme inhibitor, approved
for treatment for the metastatic stage of prostate, pancreatic, breast and ovarian cancer. Due …
for treatment for the metastatic stage of prostate, pancreatic, breast and ovarian cancer. Due …
Baicalin-loaded lipid–polymer hybrid nanoparticles inhibiting the proliferation of human colon cancer: Pharmacokinetics and in vivo evaluation
This research work is focused on pharmacokinetic and biochemical experiments to assess
baicalin-loaded lipid–polymer hybrid nanoparticles (LPHNPs) with colon-targeting …
baicalin-loaded lipid–polymer hybrid nanoparticles (LPHNPs) with colon-targeting …
Ribociclib-loaded ethylcellulose-based nanosponges: Formulation, physicochemical characterization, and cytotoxic potential against breast cancer
In the present study, ribociclib-loaded nanosponges (RCNs) composed of ethylcellulose and
polyvinyl alcohol were developed using an emulsion-solvent evaporation method …
polyvinyl alcohol were developed using an emulsion-solvent evaporation method …
Core-shell Pluronic F127/chitosan based nanoparticles for effective delivery of methotrexate in the management of rheumatoid arthritis
A Shafiq, A Madni, S Khan, H Sultana, H Shah… - International Journal of …, 2022 - Elsevier
This study was designed to improve oral bioavailability of the methotrexate (MTX) by
sustaining its release profile and integration into core-shell polymeric nanoparticles. The self …
sustaining its release profile and integration into core-shell polymeric nanoparticles. The self …
Effect of pH, temperature and native cyclodextrins on aqueous solubility of baricitinib
A Garibyan, E Delyagina, M Agafonov, I Khodov… - Journal of Molecular …, 2022 - Elsevier
Baricitinib is a novel drug recommended in 2017 for the treatment of rheumatoid arthritis and
other inflammatory diseases. The application of baricitinib can be restricted by its poor …
other inflammatory diseases. The application of baricitinib can be restricted by its poor …
Assessing the solubility of baricitinib and drug uptake in different tissues using absorption and fluorescence spectroscopies
R Mohammadi-Meyabadi, N Beirampour, N Garrós… - Pharmaceutics, 2022 - mdpi.com
The low water solubility of baricitinib (BCT) limits the development of new formulations for
the topical delivery of the drug. The aims of this study were to assess the solubility of BCT in …
the topical delivery of the drug. The aims of this study were to assess the solubility of BCT in …