Current status of potential therapeutic candidates for the COVID-19 crisis

J Zhang, B Xie, K Hashimoto - Brain, behavior, and immunity, 2020 - Elsevier
Abstract As of April 15, 2020, the ongoing coronavirus disease 2019 (COVID-2019)
pandemic has swept through 213 countries and infected more than 1,870,000 individuals …

[HTML][HTML] Macrophages in lung injury, repair, and fibrosis

P Cheng, S Li, H Chen - Cells, 2021 - mdpi.com
Fibrosis progression in the lung commonly results in impaired functional gas exchange,
respiratory failure, or even death. In addition to the aberrant activation and differentiation of …

[HTML][HTML] Pathogenesis of acute respiratory distress syndrome

LA Huppert, MA Matthay… - Seminars in respiratory and …, 2019 - thieme-connect.com
Acute respiratory distress syndrome (ARDS) is a syndrome of acute respiratory failure
caused by noncardiogenic pulmonary edema. Despite five decades of basic and clinical …

Preclinical efficacy and clinical safety of clinical‐grade nebulized allogenic adipose mesenchymal stromal cells‐derived extracellular vesicles

M Shi, Q Yang, A Monsel, J Yan, C Dai… - Journal of …, 2021 - Wiley Online Library
Mesenchymal stromal cell‐derived extracellular vesicles (MSC‐EVs) turn out to be a
promising source of cell‐free therapy. Here, we investigated the biodistribution and effect of …

Mitochondrial transfer via tunneling nanotubes is an important mechanism by which mesenchymal stem cells enhance macrophage phagocytosis in the in vitro and in …

MV Jackson, TJ Morrison, DF Doherty, DF McAuley… - Stem …, 2016 - academic.oup.com
Mesenchymal stromal cells (MSC) have been reported to improve bacterial clearance in
preclinical models of Acute Respiratory Distress Syndrome (ARDS) and sepsis. The …

Mesenchymal stem cell‐based therapy of inflammatory lung diseases: current understanding and future perspectives

CR Harrell, R Sadikot, J Pascual… - Stem cells …, 2019 - Wiley Online Library
During acute or chronic lung injury, inappropriate immune response and/or aberrant repair
process causes irreversible damage in lung tissue and most usually results in the …

[HTML][HTML] MSC based therapies—new perspectives for the injured lung

J Behnke, S Kremer, T Shahzad, CM Chao… - Journal of clinical …, 2020 - mdpi.com
Chronic lung diseases pose a tremendous global burden. At least one in four people suffer
from severe pulmonary sequelae over the course of a lifetime. Despite substantial …

[HTML][HTML] MSCs and inflammatory cells crosstalk in regenerative medicine: concerted actions for optimized resolution driven by energy metabolism

V Planat-Benard, A Varin, L Casteilla - Frontiers in immunology, 2021 - frontiersin.org
Mesenchymal stromal cells (MSCs) are currently widely used in cell based therapy
regarding to their remarkable efficacy in controlling the inflammatory status in patients …

Fifty Years of Research in ARDS.Cell-based Therapy for Acute Respiratory Distress Syndrome. Biology and Potential Therapeutic Value

JG Laffey, MA Matthay - American journal of respiratory and critical …, 2017 - atsjournals.org
On the basis of several preclinical studies, cell-based therapy has emerged as a potential
new therapeutic for acute respiratory distress syndrome (ARDS). Of the various cell-based …

Mesenchymal stem cell therapy for acute respiratory distress syndrome: from basic to clinics

H Qin, A Zhao - Protein & cell, 2020 - academic.oup.com
The 2019 novel coronavirus disease (COVID-19), caused by the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), has occurred in China and around the world. SARS …