Negatively charged tissues are ubiquitous in the human body and are associated with a
number of common diseases yet remain an outstanding challenge for targeted drug delivery …

Recent years have witnessed significant increase in both fundamental and clinical studies
evaluating DDS for osteoarthritis. Steroid encapsulating polymeric microparticles for longer …

Osteoarthritis (OA) and rheumatoid arthritis (RA) are chronic and progressive inflammatory
joint diseases that affect a large population worldwide. Intra-articular administration of …

Bone-related diseases refer to a group of skeletal disorders that are characterized by bone
and cartilage destruction. Conventional approaches can regulate bone homeostasis to a …

Gene therapy offers the possibility to skip, repair, or silence faulty genes or to stimulate the
immune system to fight against disease by delivering therapeutic nucleic acids (NAs) to a …

The transcription factor nuclear factor-κB (NF-κB) is a critical regulator of the immune
response, inflammation, cell growth, and survival. Canonical and non-canonical pathways …

Osteoarthritis (OA) is a degenerative joint disease and is the main cause of chronic pain and
functional disability in adults. Articular cartilage is a hydrated soft tissue that is composed of …

The management of osteoarthritis (OA) is a clinical challenge due to the particular avascular,
dense, and occluded tissue structure. Despite numerous clinical reports and animal studies …

Osteoarthritis (OA) is one of the most common joint diseases currently, characterized by the
gradual degradation of cartilage, remodeling of subchondral bone, development of synovitis …

“Extracellular vesicles”(EVs) is a term gathering biological particles released from cells that
act as messengers for cell-to-cell communication. Like cells, EVs have a membrane with a …