Pediatric non alcoholic fatty liver disease: old and new concepts on development, progression, metabolic insight and potential treatment targets

V Giorgio, F Prono, F Graziano, V Nobili - BMC pediatrics, 2013 - Springer
Nonalcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease in
children. NAFLD has emerged to be extremely prevalent, and predicted by obesity and male …

[PDF][PDF] Advances in pediatric nonalcoholic fatty liver disease

R Loomba, CB Sirlin, JB Schwimmer, JE Lavine - Hepatology, 2009 - Wiley Online Library
Nonalcoholic fatty liver disease (NAFLD) has emerged as the leading cause of chronic liver
disease in children and adolescents in the United States. A two‐to three‐fold rise in the rates …

Estrogen regulation of apoptosis: how can one hormone stimulate and inhibit?

JS Lewis-Wambi, VC Jordan - Breast cancer research, 2009 - Springer
The link between estrogen and the development and proliferation of breast cancer is well
documented. Estrogen stimulates growth and inhibits apoptosis through estrogen receptor …

[HTML][HTML] Pediatric fatty liver disease: role of ethnicity and genetics

P Marzuillo, EM del Giudice… - World journal of …, 2014 - ncbi.nlm.nih.gov
Non-alcoholic fatty liver disease (NAFLD) comprehends a wide range of conditions,
encompassing from fatty liver or steatohepatitis with or without fibrosis, to cirrhosis and its …

[HTML][HTML] Pediatric non-alcoholic fatty liver disease: new insights and future directions

P Marzuillo, EM Del Giudice… - World Journal of …, 2014 - ncbi.nlm.nih.gov
One of the most common complications of childhood obesity is the non-alcoholic fatty liver
disease (NAFLD), which is the most common form of liver disease in children. NAFLD is …

The relationships between snail1 and estrogen receptor signaling in breast cancer cells

AM Scherbakov, OE Andreeva… - Journal of cellular …, 2012 - Wiley Online Library
The loss of hormonal dependency of breast tumor cells is often accompanied with the
appearance of epithelial‐mesenchymal transition (EMT) features and increase in cell …

Metabolic associated fatty liver disease in children—from atomistic to holistic

CO Mărginean, LE Meliț, MO Săsăran - Biomedicines, 2021 - mdpi.com
Non-alcoholic fatty liver disease has become the most common chronic liver disease in
children due to the alarmingly increasing incidence of pediatric obesity. It is well …

Endocrinotherapy resistance of prostate and breast cancer: Importance of the NF‑κB pathway

X Wang, Y Fang, W Sun, Z Xu… - International …, 2020 - spandidos-publications.com
Prostate cancer (PCa) and breast cancer (BCa) are two common sex hormone‑related
cancer types with high rates of morbidity, and are leading causes of cancer death globally in …

Molecular mechanisms of hormone resistance of breast cancer

AM Scherbakov, MA Krasil'Nikov… - Bulletin of experimental …, 2013 - Springer
More than 70% malignant mammary tumors contain steroid hormone receptors; this
suggests the possibility of hormone therapy in the majority of patients with breast cancer …

The pitfall of the transient, inconsistent anticancer capacity of antiestrogens and the mechanism of apparent antiestrogen resistance

Z Suba - Drug design, development and therapy, 2015 - Taylor & Francis
Although antiestrogens have been available for breast cancer therapy since the early 1970s,
neither their inconsistent anticancer capacity nor the developing antiestrogen resistance of …