Toxoplasma gondii is known to infect a considerable number of mammalian and avian
species and a substantial proportion of the world's human population. The parasite has an …

The intracellular parasite Toxoplasma gondii has long provided a tractable experimental
system to investigate how the immune system deals with intracellular infections. This review …

An early hallmark of Toxoplasma gondii infection is the rapid control of the parasite
population by a potent multifaceted innate immune response that engages resident and …

Toxoplasma gondii is an incredibly successful parasite owing in part to its ability to persist
within cells for the life of the host. Remarkably, at least 350 host species of T. gondii have …

Toxoplasma gondii is a parasitic protist infecting a wide group of warm-blooded animals,
ranging from birds to humans. While this infection is usually asymptomatic in healthy …

A majority of emerging infectious diseases in humans are zoonoses. Understanding factors
that influence the emergence and transmission of zoonoses is pivotal for their prevention …

Macrophages play an essential role in the early immune response against Toxoplasma and
are the cell type preferentially infected by the parasite in vivo. Interferon gamma (IFNγ) elicits …

Examining host–pathogen interactions in animals can capture aspects of infection that are
obscured in cell culture. Using CRISPR-based screens, we functionally profile the entire …

The parasitophorous vacuole is a unique replicative niche for apicomplexan parasites,
including Toxoplasma gondii. Derived from host plasma membrane, the vacuole is rendered …

Toxoplasma gondii secretes protein effectors to subvert the human immune system
sufficiently to establish a chronic infection. Relative to murine infections, little is known about …