Tyrosine kinase inhibitors (TKIs), as an important class of chemotherapeutic drugs, induce
apoptosis by altering the path of the cellular signal, resulting in cell death. However, some …

Simple Summary Hepatocellular carcinoma (HCC) is a highly incident and deadly malignant
neoplasia, and only a few anti-HCC drugs are currently available. Thus, the development of …

Non-small cell lung cancer (NSCLC) is a global concern as one of the leading causes of
cancer deaths. The treatment options for NSCLC are limited to systemic chemotherapy …

Pancreatic cancer remains one of the most lethal malignancies worldwide. The combination
of the first-line standard agent gemcitabine (GEM) with the molecular-targeted drug erlotinib …

Immune system deficiencies are crucial in the progression of cancer, predominantly
because immune cells are not stimulated by cytokines to eradicate cancer cells …

Cancer is generally considered a result of genetic mutations that cause epigenetic changes,
leading to anomalous cellular behavior. Since 1970s, an increasing understanding of the …

Lung malignancies accounted for 11% of cancers worldwide in 2020 and remained the
leading cause of cancer deaths. About 80% of lung cancers belong to non-small cell lung …

The uniqueness of paclitaxel's antimitotic action mechanism has fueled research toward its
application in more effective and safer cancer treatments. However, the low water solubility …

Cholesterol remains a vital molecule required for life; however, increasing evidence exists
implicating cholesterol in cancer development and progression. Numerous studies …

Colorectal cancer (CRC) is the third most diagnosed cancer type globally and ranks second
in cancer-related deaths. With the current treatment possibilities, a definitive, safe, and …