Mechanistic pathways of sex differences in cardiovascular disease

V Regitz-Zagrosek, G Kararigas - Physiological reviews, 2017 - journals.physiology.org
Major differences between men and women exist in epidemiology, manifestation,
pathophysiology, treatment, and outcome of cardiovascular diseases (CVD), such as …

Cardiac mitochondria and arrhythmias

DA Brown, B O'Rourke - Cardiovascular research, 2010 - academic.oup.com
Despite a high prevalence of sudden cardiac death throughout the world, the mechanisms
that lead to ventricular arrhythmias are not fully understood. Over the last 20 years, a …

Gender-related differences in ion-channel and transporter subunit expression in non-diseased human hearts

N Gaborit, A Varro, S Le Bouter, V Szuts… - Journal of molecular and …, 2010 - Elsevier
Gender-related differences in ventricular electrophysiology are known to be important
determinants of human arrhythmic risk, but the underlying molecular basis is poorly …

[HTML][HTML] Recent advances in understanding sex differences in cardiac repolarization

AF James, SCM Choisy, JC Hancox - Progress in biophysics and molecular …, 2007 - Elsevier
A number of gender differences exist in the human electrocardiogram (ECG): the P-wave
and PR intervals are slightly longer in men than in women, whilst women have higher …

Deficiency of LKB1 in heart prevents ischemia-mediated activation of AMPKα2 but not AMPKα1

K Sakamoto, E Zarrinpashneh… - American Journal …, 2006 - journals.physiology.org
Recent studies indicate that the LKB1 is a key regulator of the AMP-activated protein kinase
(AMPK), which plays a crucial role in protecting cardiac muscle from damage during …

Gender differences in cardioprotection against ischemia/reperfusion injury in adult rat hearts: focus on Akt and protein kinase C signaling

S Bae, L Zhang - Journal of Pharmacology and Experimental …, 2005 - ASPET
Previous studies have reported the sex differences in heart susceptibility to
ischemia/reperfusion (I/R) injury, but the mechanisms are not understood. The present study …

Susceptibility of the heart to ischaemia–reperfusion injury and exercise‐induced cardioprotection are sex‐dependent in the rat

DA Brown, JM Lynch, CJ Armstrong… - The Journal of …, 2005 - Wiley Online Library
The cardioprotective effects of short‐term exercise against myocardial ischaemia–
reperfusion injury in male and female rats were examined. We subjected male and female …

Exercise preconditioning of the myocardium

AN Kavazis - Sports medicine, 2009 - Springer
Diseases of the heart (eg myocardial ischaemia reperfusion injury) remain the major cause
of death in the industrialized world. Therefore, developing a pragmatic countermeasure to …

Cardioprotection afforded by chronic exercise is mediated by the sarcolemmal, and not the mitochondrial, isoform of the KATP channel in the rat

DA Brown, AJ Chicco, KN Jew… - The Journal of …, 2005 - Wiley Online Library
This study was conducted to examine the role of myocardial ATP‐sensitive potassium
(KATP) channels in exercise‐induced protection from ischaemia–reperfusion (I–R) injury …

The Sulfonylurea Receptor, an Atypical ATP-Binding Cassette Protein, and Its Regulation of the KATP Channel

MA Burke, RK Mutharasan, H Ardehali - Circulation research, 2008 - Am Heart Assoc
ATP-binding cassette (ABC) proteins are highly conserved and widely expressed throughout
nature and found in all organisms, both prokaryotic and eukaryotic. They mediate myriad …