A brave new world of RNA-binding proteins
RNA-binding proteins (RBPs) are typically thought of as proteins that bind RNA through one
or multiple globular RNA-binding domains (RBDs) and change the fate or function of the …
or multiple globular RNA-binding domains (RBDs) and change the fate or function of the …
A census of human RNA-binding proteins
Post-transcriptional gene regulation (PTGR) concerns processes involved in the maturation,
transport, stability and translation of coding and non-coding RNAs. RNA-binding proteins …
transport, stability and translation of coding and non-coding RNAs. RNA-binding proteins …
Exon junction complex shapes the m6A epitranscriptome
Abstract N6-methyladenosine (m6A), the most abundant modification of mRNA, is essential
for normal development and dysregulation promotes cancer. m6A is highly enriched in the …
for normal development and dysregulation promotes cancer. m6A is highly enriched in the …
Differential m6A, m6Am, and m1A demethylation mediated by FTO in the cell nucleus and cytoplasm
FTO, the first RNA demethylase discovered, mediates the demethylation of internal N 6-
methyladenosine (m 6 A) and N 6, 2-O-dimethyladenosine (m 6 A m) at the+ 1 position from …
methyladenosine (m 6 A) and N 6, 2-O-dimethyladenosine (m 6 A m) at the+ 1 position from …
The human RNA-binding proteome and its dynamics during translational arrest
J Trendel, T Schwarzl, R Horos, A Prakash, A Bateman… - Cell, 2019 - cell.com
Proteins and RNA functionally and physically intersect in multiple biological processes,
however, currently no universal method is available to purify protein-RNA complexes. Here …
however, currently no universal method is available to purify protein-RNA complexes. Here …
Comprehensive identification of RNA–protein interactions in any organism using orthogonal organic phase separation (OOPS)
RML Queiroz, T Smith, E Villanueva… - Nature …, 2019 - nature.com
Existing high-throughput methods to identify RNA-binding proteins (RBPs) are based on
capture of polyadenylated RNAs and cannot recover proteins that interact with …
capture of polyadenylated RNAs and cannot recover proteins that interact with …
[HTML][HTML] RNA-induced conformational switching and clustering of G3BP drive stress granule assembly by condensation
J Guillén-Boixet, A Kopach, AS Holehouse, S Wittmann… - Cell, 2020 - cell.com
Stressed cells shut down translation, release mRNA molecules from polysomes, and form
stress granules (SGs) via a network of interactions that involve G3BP. Here we focus on the …
stress granules (SGs) via a network of interactions that involve G3BP. Here we focus on the …
Splicing and transcription touch base: co-transcriptional spliceosome assembly and function
Several macromolecular machines collaborate to produce eukaryotic messenger RNA. RNA
polymerase II (Pol II) translocates along genes that are up to millions of base pairs in length …
polymerase II (Pol II) translocates along genes that are up to millions of base pairs in length …
The selection and function of cell type-specific enhancers
The human body contains several hundred cell types, all of which share the same genome.
In metazoans, much of the regulatory code that drives cell type-specific gene expression is …
In metazoans, much of the regulatory code that drives cell type-specific gene expression is …
Synthesizing biomaterials in living organisms
X Zhang, J Wang, Y Zhang, Z Yang, J Gao… - Chemical Society …, 2023 - pubs.rsc.org
Living organisms fabricate biomacromolecules such as DNA, RNA, and proteins by the self-
assembly process. The research on the mechanism of biomacromolecule formation also …
assembly process. The research on the mechanism of biomacromolecule formation also …