High-pressure is a well-known perturbation method used to destabilize globular proteins. It
is perfectly reversible, which is essential for a proper thermodynamic characterization of a …

Amelotin is an intrinsically disordered protein (IDP) rich in Pro residues and is involved in
hydroxyapatite mineralization. It rapidly oligomerizes under physiological conditions of pH …

In general, small proteins rapidly fold on the timescale of milliseconds or less. For proteins
with a substantial volume difference between the folded and unfolded states, their …

Proteins usually exist in multiple conformational states in solution. High pressure NMR
spectroscopy is a well-suited method to identify these states. In addition, these states can be …

Proteins involved in signal transduction exist in more than one conformational state and thus
generally permit a new type of allosteric inhibition by targeting their rare interaction states …

Pressure and temperature are the two fundamental variables of thermodynamics.
Temperature and chemical perturbation are central experimental tools for the exploration of …

The impact of pressure on the backbone 15N, 1H and 13C chemical shifts in N‐terminally
acetylated α‐synuclein has been evaluated over a pressure range 1–2500 bar. Even while …

The adenosine di-phosphate (ADP) ribosylation factor (Arf) small guanosine tri-phosphate
(GTP) ases function as molecular switches to activate signaling cascades that control …

The analysis of pressure induced changes in the chemical shift of proteins allows statements
on structural fluctuations proteins exhibit at ambient pressure. The inherent issue of …

The classic isoforms of myelin basic protein (MBP) are essential for the formation and
maintenance of myelin in the central nervous system of higher vertebrates. The protein is …