Mechanics of the tricuspid valve—From clinical diagnosis/treatment, in-vivo and in-vitro investigations, to patient-specific biomechanical modeling

CH Lee, DW Laurence, CJ Ross, KE Kramer, AR Babu… - Bioengineering, 2019 - mdpi.com
Proper tricuspid valve (TV) function is essential to unidirectional blood flow through the right
side of the heart. Alterations to the tricuspid valvular components, such as the TV annulus …

An investigation of the anisotropic mechanical properties and anatomical structure of porcine atrioventricular heart valves

S Jett, D Laurence, R Kunkel, AR Babu… - Journal of the …, 2018 - Elsevier
Valvular heart diseases are complex disorders, varying in pathophysiological mechanism
and affected valve components. Understanding the effects of these diseases on valve …

A detailed mechanical and microstructural analysis of ovine tricuspid valve leaflets

WD Meador, M Mathur, GP Sugerman, T Jazwiec… - Acta biomaterialia, 2020 - Elsevier
The tricuspid valve ensures unidirectional blood flow from the right atrium to the right
ventricle. The three tricuspid leaflets operate within a dynamic stress environment of shear …

An investigation of regional variations in the biaxial mechanical properties and stress relaxation behaviors of porcine atrioventricular heart valve leaflets

D Laurence, C Ross, S Jett, C Johns, A Echols… - Journal of …, 2019 - Elsevier
The facilitation of proper blood flow through the heart depends on proper function of heart
valve components, and alterations to any component can lead to heart disease or failure …

Comparative mechanical, morphological, and microstructural characterization of porcine mitral and tricuspid leaflets and chordae tendineae

A Pokutta-Paskaleva, F Sulejmani, M DelRocini, W Sun - Acta biomaterialia, 2019 - Elsevier
Background Healthy function of tricuspid valve (TV) structures is essential to avoid tricuspid
regurgitation (TR) and may significantly improve disease prognosis. Mitral valve (MV) …

Integration of polarized spatial frequency domain imaging (pSFDI) with a biaxial mechanical testing system for quantification of load-dependent collagen architecture …

SV Jett, LT Hudson, R Baumwart, BN Bohnstedt, A Mir… - Acta biomaterialia, 2020 - Elsevier
Collagen fiber networks provide the structural strength of tissues, such as tendons, skin and
arteries. Quantifying the fiber architecture in response to mechanical loads is essential …

Effects of enzyme-based removal of collagen and elastin constituents on the biaxial mechanical responses of porcine atrioventricular heart valve anterior leaflets

CJ Ross, DW Laurence, AL Echols, AR Babu, T Gu… - Acta biomaterialia, 2021 - Elsevier
The leaflets of the atrioventricular heart valves (AHVs) regulate the one-directional flow of
blood through a coordination of the extracellular matrix components, including the collagen …

An investigation of layer-specific tissue biomechanics of porcine atrioventricular valve anterior leaflets

KE Kramer, CJ Ross, DW Laurence, AR Babu, Y Wu… - Acta Biomaterialia, 2019 - Elsevier
Atrioventricular heart valves (AHVs) are composed of structurally complex and
morphologically heterogeneous leaflets. The coaptation of these leaflets during the cardiac …

Finite element analysis of tricuspid valve deformation from multi-slice computed tomography images

F Kong, T Pham, C Martin, R McKay, C Primiano… - Annals of biomedical …, 2018 - Springer
Despite the growing clinical interest in the tricuspid valve (TV), there is an incomplete
understanding of TV biomechanics which is important in normal TV function and successful …

An investigation of the effect of freezing storage on the biaxial mechanical properties of excised porcine tricuspid valve anterior leaflets

GA Duginski, CJ Ross, DW Laurence, CH Johns… - Journal of the …, 2020 - Elsevier
The atrioventricular heart valve (AHV) leaflets are critical to the facilitation of proper
unidirectional blood flow through the heart. Previously, studies have been conducted to …