Treating primary aldosteronism-induced hypertension: novel approaches and future outlooks

N Mullen, J Curneen, PT Donlon, P Prakash… - Endocrine …, 2024 - academic.oup.com
Primary aldosteronism (PA) is the most common cause of secondary hypertension and is
associated with increased morbidity and mortality when compared with blood pressure …

Hypertension: the role of biochemistry in the diagnosis and management

PM O'Shea, TP Griffin, M Fitzgibbon - Clinica Chimica Acta, 2017 - Elsevier
Hypertension is defined as a persistently elevated blood pressure≥ 140/90 mm Hg. It is an
important treatable risk factor for cardiovascular disease, with a high prevalence in the …

11C‐Metomidate PET/CT is a useful adjunct for lateralization of primary aldosteronism in routine clinical practice

PM O'Shea, D O'Donoghue, W Bashari… - Clinical …, 2019 - Wiley Online Library
Objective To describe clinical practice experience of 11C‐Metomidate PET/CT as an adjunct
to adrenal vein sampling (AVS) in the lateralization of aldosterone‐producing adenomas …

[HTML][HTML] The effect of antihypertensive medications on testing for primary aldosteronism

P Jędrusik, B Symonides, J Lewandowski… - Frontiers in …, 2021 - frontiersin.org
Primary aldosteronism (PA) is a potentially curable form of secondary hypertension caused
by excessive renin-independent aldosterone secretion, leading to increased target organ …

[HTML][HTML] Aldosterone to renin ratio as screening tool in primary aldosteronism

K Schilbach, RK Junnila… - … Clinical Endocrinology & …, 2019 - thieme-connect.com
Primary aldosteronism (PA) is a severe and often underdiagnosed form of secondary
hypertension. Determining the aldosterone to renin ratio (ARR) in hypertensive patients has …

The aldosterone to renin ratio in the diagnosis of primary aldosteronism: promises and challenges

PM O'Shea, TP Griffin, S Denieffe… - … journal of clinical …, 2019 - Wiley Online Library
The complexity of evaluating patients for secondary treatable causes of hypertension is
underappreciated. Primary aldosteronism (PA) is the most prevalent cause of secondary …

The effects of carvedilol, metoprolol and propranolol on cisplatin-induced kidney injury

A Esmaeeli, Z Keshavarz, F Dehdar… - Drug and Chemical …, 2022 - Taylor & Francis
The β-adrenoceptor blockers may have anti-oxidant properties or induce β-arrestin
recruitment beyond classical desensitization of receptor/G protein coupling, offering …

The effect of medication on the aldosterone‐to‐renin ratio. A critical review of the literature

RM Alnazer, GP Veldhuizen, AA Kroon… - The Journal of …, 2021 - Wiley Online Library
The aldosterone‐to‐renin ratio (ARR) is a common screening test for primary aldosteronism
in hypertensives. However, patients often use medications that could confound the ARR …

Associations between glycaemic control and activation of the renin-angiotensin-aldosterone system in participants with type 2 diabetes mellitus and hypertension

TP Griffin, D Wall, GA Browne… - Annals of clinical …, 2018 - journals.sagepub.com
Introduction Hyperglycaemia increases succinate concentrations and succinate receptor
activation in the kidney resulting in renin release. The aim of our study was to determine if …

[HTML][HTML] Real-world effectiveness of mineralocorticoid receptor antagonists in primary aldosteronism

Y Tezuka, AF Turcu - Frontiers in Endocrinology, 2021 - frontiersin.org
Objective To investigate how often target renin is pursued and achieved in patients with
primary aldosteronism (PA) and other low renin hypertension (LRH) treated with …