Myopia, also known as short-sightedness or near-sightedness, is a very common condition
that typically starts in childhood. Severe forms of myopia (pathologic myopia) are associated …

More and more in-depth studies have revealed that the occurrence and development of
tumors depend on gene mutation and tumor heterogeneity. The most important …

Recent studies of N-terminal acetylation have identified new N-terminal acetyltransferases
(NATs) and expanded the known functions of these enzymes beyond their roles as ribosome …

Specificity of eukaryotic protein degradation is determined by E3 ubiquitin ligases and their
selective binding to protein motifs, termed" degrons," in substrates for ubiquitin-mediated …

Neddylation, a post-translational modification that conjugates an ubiquitin-like protein
NEDD8 to substrate proteins, is an important biochemical process that regulates protein …

Protein neddylation is a post-translational modification, and its best recognized substrates
are cullin family proteins, which are the core component of Cullin-RING ligases (CRLs) …

Covalent modification of proteins with ubiquitin is essential for the majority of biological
processes in mammalian cells. Numerous proteins are conjugated with single or multiple …

Most eukaryotic proteins are N-terminally acetylated, but the functional impact on a global
scale has remained obscure. Using genome-wide CRISPR knockout screens in human …

Nα-terminal acetylation (Nt-acetylation) occurs very frequently and is found in most proteins
in eukaryotes. Despite the pervasiveness and universality of Nt-acetylation, its general …

Approximately 40% of the mammalian proteome undergoes N-terminal methionine excision
and acetylation, mediated sequentially by methionine aminopeptidase (MetAP) and N …