The role of oxidative stress-mediated inflammation in the development of T2DM-induced diabetic nephropathy: possible preventive action of tannins and other …

G Sahakyan, A Vejux, N Sahakyan - Molecules, 2022 - mdpi.com
Diabetic nephropathy is manifested in more than 10% of people with diabetes. It is a
common cause of kidney failure and end-stage kidney disease. Understanding of …

[HTML][HTML] Type 2 diabetes mellitus and neurodegenerative disorders: The mitochondrial connection

IR Baduini, JEC Vildosola, S Kavehmoghaddam… - Pharmacological …, 2024 - Elsevier
The incidence of type 2 diabetes mellitus (T2DM) has increased in our society in recent
decades as the population ages, and this trend is not expected to revert. This is the same for …

Mitochondrial protein dysfunction in pathogenesis of neurological diseases

L Wang, Z Yang, X He, S Pu, C Yang, Q Wu… - Frontiers in Molecular …, 2022 - frontiersin.org
Mitochondria are essential organelles for neuronal function and cell survival. Besides the
well-known bioenergetics, additional mitochondrial roles in calcium signaling, lipid …

Genetically encoded ATP biosensors for direct monitoring of cellular ATP dynamics

D White III, Q Yang - Cells, 2022 - mdpi.com
Adenosine 5′-triphosphate, or ATP, is the primary molecule for storing and transferring
energy in cells. ATP is mainly produced via oxidative phosphorylation in mitochondria, and …

COVID‐19 and neurodegeneration: The mitochondrial connection

CA Denaro, YI Haloush, SY Hsiao, JJ Orgera… - Aging …, 2022 - Wiley Online Library
There is still a significant lack of knowledge regarding many aspects of the etiopathology
and consequences of the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) …

The Proteome Profile of Olfactory Ecto-Mesenchymal Stem Cells-Derived from Patients with Familial Alzheimer's Disease Reveals New Insights for AD Study

LJ Rochín-Hernández, MA Jiménez-Acosta… - International Journal of …, 2023 - mdpi.com
Alzheimer's disease (AD), the most common neurodegenerative disease and the first cause
of dementia worldwide, has no effective treatment, and its pathological mechanisms are not …

Mitochondrial inorganic polyphosphate is required to maintain proteostasis within the organelle

RT Da Costa, P Urquiza, MM Perez, YG Du… - Frontiers in Cell and …, 2024 - frontiersin.org
The existing literature points towards the presence of robust mitochondrial mechanisms
aimed at mitigating protein dyshomeostasis within the organelle. However, the precise …

Enzymatic depletion of mitochondrial inorganic polyphosphate (polyP) increases the generation of reactive oxygen species (ROS) and the activity of the pentose …

V Hambardikar, M Guitart-Mampel, ER Scoma… - Antioxidants, 2022 - mdpi.com
Inorganic polyphosphate (polyP) is an ancient biopolymer that is well preserved throughout
evolution and present in all studied organisms. In mammals, it shows a high co-localization …

Human prune regulates the metabolism of mammalian inorganic polyphosphate and bioenergetics

ER Scoma, RT Da Costa, HH Leung, P Urquiza… - International journal of …, 2023 - mdpi.com
Inorganic polyphosphate (polyP) is an evolutionarily conserved and ubiquitous polymer that
is present in all studied organisms. PolyP consists of orthophosphates (Pi) linked together by …

Mitochondrial inorganic polyphosphate (polyP) is a potent regulator of mammalian bioenergetics in SH-SY5Y cells: a proteomics and metabolomics study

M Guitart-Mampel, P Urquiza… - Frontiers in Cell and …, 2022 - frontiersin.org
Inorganic polyphosphate (polyP) is an ancient, ubiquitous, and well-conserved polymer
which is present in all the studied organisms. It is formed by individual subunits of …