Measuring immunity to SARS-CoV-2 infection: comparing assays and animal models
The rapid scale-up of research on coronavirus disease 2019 (COVID-19) has spawned a
large number of potential vaccines and immunotherapies, accompanied by a …
large number of potential vaccines and immunotherapies, accompanied by a …
Lethality of SARS-CoV-2 infection in K18 human angiotensin-converting enzyme 2 transgenic mice
FS Oladunni, JG Park, PA Pino, O Gonzalez… - Nature …, 2020 - nature.com
Vaccine and antiviral development against SARS-CoV-2 infection or COVID-19 disease
would benefit from validated small animal models. Here, we show that transgenic mice …
would benefit from validated small animal models. Here, we show that transgenic mice …
Responses to acute infection with SARS-CoV-2 in the lungs of rhesus macaques, baboons and marmosets
Non-human primate models will expedite therapeutics and vaccines for coronavirus disease
2019 (COVID-19) to clinical trials. Here, we compare acute severe acute respiratory …
2019 (COVID-19) to clinical trials. Here, we compare acute severe acute respiratory …
ACTIVating resources for the COVID-19 pandemic: in vivo models for vaccines and therapeutics
JA Hewitt, C Lutz, WC Florence, MLM Pitt, S Rao… - Cell Host & Microbe, 2020 - cell.com
The Preclinical Working Group of Accelerating COVID-19 Therapeutic Interventions and
Vaccines (ACTIV), a public-private partnership spearheaded by the National Institutes of …
Vaccines (ACTIV), a public-private partnership spearheaded by the National Institutes of …
Comparison of rhesus and cynomolgus macaques as an infection model for COVID-19
FJ Salguero, AD White, GS Slack… - Nature …, 2021 - nature.com
A novel coronavirus, SARS-CoV-2, has been identified as the causative agent of the current
COVID-19 pandemic. Animal models, and in particular non-human primates, are essential to …
COVID-19 pandemic. Animal models, and in particular non-human primates, are essential to …
[HTML][HTML] Acute respiratory distress in aged, SARS-CoV-2–infected African green monkeys but not rhesus macaques
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induces a wide range of
disease severity, ranging from asymptomatic infection to a life-threating illness, particularly …
disease severity, ranging from asymptomatic infection to a life-threating illness, particularly …
High affinity nanobodies block SARS-CoV-2 spike receptor binding domain interaction with human angiotensin converting enzyme
There are currently few approved effective treatments for SARS-CoV-2, the virus responsible
for the COVID-19 pandemic. Nanobodies are 12–15 kDa single-domain antibody fragments …
for the COVID-19 pandemic. Nanobodies are 12–15 kDa single-domain antibody fragments …
A prefusion SARS-CoV-2 spike RNA vaccine is highly immunogenic and prevents lung infection in non-human primates
AB Vogel, I Kanevsky, Y Che, KA Swanson, A Muik… - BioRxiv, 2020 - biorxiv.org
To contain the coronavirus disease 2019 (COVID-19) pandemic, a safe and effective
vaccine against the new severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is …
vaccine against the new severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is …
IFN signaling and neutrophil degranulation transcriptional signatures are induced during SARS-CoV-2 infection
SARS-CoV-2 virus has infected more than 92 million people worldwide resulting in the
Coronavirus disease 2019 (COVID-19). Using a rhesus macaque model of SARS-CoV-2 …
Coronavirus disease 2019 (COVID-19). Using a rhesus macaque model of SARS-CoV-2 …
SARS-CoV-2 induces robust germinal center CD4 T follicular helper cell responses in rhesus macaques
Y Shaan Lakshmanappa, SR Elizaldi, JW Roh… - Nature …, 2021 - nature.com
CD4 T follicular helper (Tfh) cells are important for the generation of durable and specific
humoral protection against viral infections. The degree to which SARS-CoV-2 infection …
humoral protection against viral infections. The degree to which SARS-CoV-2 infection …