Motile and non-motile (primary) cilia are nearly ubiquitous cellular organelles. The
dysfunction of cilia causes diseases known as ciliopathies. The number of reported …

The primary cilium is a hair-like surface-exposed organelle of the eukaryotic cell that
decodes a variety of signals—such as odorants, light and Hedgehog morphogens—by …

Signaling receptors dynamically exit cilia upon activation of signaling pathways such as
Hedgehog. Here, we find that when activated G protein-coupled receptors (GPCRs) fail to …

Eukaryotic cilia and flagella are evolutionarily conserved organelles that protrude from the
cell surface. The unique location and properties of cilia allow them to function in vital …

Detailed structural, biochemical, cell biological, and genetic studies of any gene/protein are
required to develop models of its actions in cells. Studying a protein family in the aggregate …

The motile and sensory functions of cilia and flagella are indispensable for human health.
Cilia assembly requires a dedicated protein shuttle, intraflagellar transport (IFT), a …

A diffusion barrier at the transition zone enables the compartmentalization of signaling
molecules by cilia. The BBSome and the small guanosine triphosphatase Arl6, which …

Cilia are plasma membrane protrusions that act as cellular propellers or antennae. To
perform these functions, cilia must maintain a composition distinct from those of the …

Cilia are ubiquitous eukaryotic organelles impotant for cellular motility, signaling, and
sensory reception. Cilium formation requires intraflagellar transport of structural and …

While cilia are recognized as important signaling organelles, the extent of ciliary functions
remains unknown because of difficulties in cataloguing proteins from mammalian primary …