Our understanding of the function of the transcriptional regulators YAP and TAZ (YAP/TAZ)
in cancer is advancing. In this Review, we provide an update on recent progress in YAP/TAZ …

YAP and TAZ are transcriptional activators pervasively induced in several human solid
tumours and their functions in cancer cells are the focus of intense investigation. These …

How cells sense tissue stiffness to guide cell migration is a fundamental question in
development, fibrosis and cancer. Although durotaxis—cell migration towards increasing …

Osteosarcoma is one of the most common primary tumours of the bone, with a 5‐year
survival rate of less than 20% after the development of metastases. Osteosarcoma is highly …

Acting as a bridge between the cytoskeleton of the cell and the extra cellular matrix (ECM),
the cell-ECM adhesions with integrins at their core, play a major role in cell signalling to …

The plasma membrane allows the cell to sense and adapt to changes in the extracellular
environment by relaying external inputs via intracellular signaling networks. One central …

Cell motility is essential for life and development. Unfortunately, cell migration is also linked
to several pathological processes, such as cancer metastasis. Cells' ability to migrate relies …

Large bone defects cannot form a callus and exhibit high complication rates even with the
best treatment strategies available. Tissue engineering approaches often use scaffolds …

Although understanding how soluble cues direct cellular processes revolutionised the study
of cell biology in the second half of the 20th century, over the last two decades, new insights …

The ability to maintain and differentiate cells in vitro is critical to many advances in the field
of bioengineering. However, on traditional, stiff (E≈ GPa) culture substrates, cells are …