The classic myelin basic protein (MBP) splice isoforms range in nominal molecular mass
from 14 to 21.5 kDa, and arise from the gene in the oligodendrocyte lineage (Golli) in …

The cellular and molecular aspects of myelin protein metabolism have recently been among
the most intensively studied in neurobiology. Myelination is a developmentally regulated …

Multiple sclerosis (MS) and a number of related distinctive diseases are characterized by the
active degradation of central nervous system (CNS) myelin, an axonal sheath comprised …

Oligodendrogenesis and oligodendrocyte precursor maturation are essential processes
during the course of central nervous system development, and lead to the myelination of …

Matrix metalloproteinases (MMPs), the key effectors of extracellular matrix remodeling, have
been demonstrated to regulate the extension of neurites from neuronal cell bodies. In this …

Recent studies have recognized G protein-coupled receptors as important regulators of
oligodendrocyte development. GPR17, in particular, is an orphan G protein-coupled …

A novel clonal cell line derived from a human glioma (HOG) was found to express some
oligodendrocyte-specific proteins including a 15-kDa form of myelin basic protein (MBP) and …

Adherence of monocytes to endothelial cells or extracellular matrices is likely to play a
critical role in triggering monocyte activation in extravascular sites of infection, chronic …

Demyelination is observed in animal models of intractable epilepsy (IE). Epileptogenesis
damages the myelin sheath and dysregulates oligodendrocyte precursor cell (OPC) …

Oligodendrocyte-formed myelin sheaths allow fast synaptic transmission in the brain and
their degeneration leads to demyelinating diseases such as multiple sclerosis …