The type I Fcε receptor (FcεRI) is one of the better understood members of its class and is
central to the immunological activation of mast cells and basophils, the key players in …

The contention and treatment of Mycobacterium tuberculosis and other bacteria that cause
infectious diseases require the use of new type of antibiotics. Pandinin 2 (Pin2) is a scorpion …

Mast cells and basophils are important contributors for development of allergic reactions.
The activation of these cells via cross‐linking of IgE bound to FcεRI by allergen causes the …

Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the growth of
renal cysts that ultimately destroy kidney function. Mutations in the PKD1 and PKD2 genes …

Polyprenol phosphate phosphoglycosyl transferases (PGTs) catalyze the first membrane-
committed step in assembly of essential glycoconjugates. Currently there is no structure …

Some mastoparan peptides extracted from social wasps display antimicrobial activity and
some are hemolytic and cytotoxic. Although the cell specificity of these peptides is complex …

Metastatic castration-resistant prostate cancer (mCRPC) has been largely resistant to
immunotherapy. Natural killer (NK) cells are cytotoxic lymphocytes that detect and kill …

Chemokines are small (8–12 kDa) effector proteins that potentiate leukocyte
chemonavigation. Beyond this role, certain chemokines have direct antimicrobial activity …

Human natural killer (NK) cells can target tumor cells in an antigen-specific manner by the
recognition of cell bound antibodies. This process induces antibody-dependent cell …

Four variants of the highly hemolytic antimicrobial peptide Pin2 were chemically synthesized
with the aim to investigate the role of the proline residue in this peptide, by replacing it with …