Oral delivery of biologics for precision medicine
The emerging field of precision medicine is rapidly growing, fostered by the advances in
genome mapping and molecular diagnosis. In general, the translation of these advances …
genome mapping and molecular diagnosis. In general, the translation of these advances …
Local delivery of macromolecules to treat diseases associated with the colon
Current treatments for intestinal diseases including inflammatory bowel diseases, irritable
bowel syndrome, and colonic bacterial infections are typically small molecule oral dosage …
bowel syndrome, and colonic bacterial infections are typically small molecule oral dosage …
Nanocomposite systems for precise oral delivery of drugs and biologics
Oral delivery is considered the favoured route of administration for both local and systemic
delivery of active molecules. Formulation of drugs in conventional systems and …
delivery of active molecules. Formulation of drugs in conventional systems and …
[HTML][HTML] Comparison of the effects of the intestinal permeation enhancers, SNAC and sodium caprate (C10): Isolated rat intestinal mucosae and sacs
C Twarog, F McCartney, SM Harrison, B Illel… - European Journal of …, 2021 - Elsevier
SNAC and C 10 are intestinal permeation enhancers (PEs) used in formulations of peptides
for oral delivery in clinical trials. Our aims were to compare their:(i) mechanism of action in …
for oral delivery in clinical trials. Our aims were to compare their:(i) mechanism of action in …
Spatiotemporally controlled calcitonin delivery: Long-term and targeted therapy of skeletal diseases
P Yu, Y Liu, J Xie, J Li - Journal of Controlled Release, 2021 - Elsevier
Bone is a connective tissue that support the entire body and protect the internal organs.
However, there are great challenges on curing intractable skeletal diseases such as …
However, there are great challenges on curing intractable skeletal diseases such as …
Application or function of citric acid in drug delivery platforms
M Pooresmaeil, S Javanbakht… - Medicinal Research …, 2022 - Wiley Online Library
Nontoxic materials with natural origin are promising materials in the designing and
preparation of the new drug delivery systems (DDSs). Today's, citric acid (CA) has attracted …
preparation of the new drug delivery systems (DDSs). Today's, citric acid (CA) has attracted …
[HTML][HTML] Calcitonin: A useful old friend
A Srinivasan, FK Wong, D Karponis - Journal of musculoskeletal & …, 2020 - ncbi.nlm.nih.gov
Calcitonin regulates blood calcium levels and possesses certain clinically useful anti-
fracture properties. Specifically, it reduces vertebral fractures in postmenopausal …
fracture properties. Specifically, it reduces vertebral fractures in postmenopausal …
Mesoporous matrices for the delivery of the broad spectrum bacteriocin, nisin A
J Flynn, S Mallen, E Durack, PM O'Connor… - Journal of colloid and …, 2019 - Elsevier
Mesoporous matrices of different pore size and chemical composition were explored as
potential delivery matrices for the broad spectrum bacteriocin, nisin A. The adsorption of …
potential delivery matrices for the broad spectrum bacteriocin, nisin A. The adsorption of …
Progress and limitations of oral peptide delivery as a potentially transformative therapy
H Tran, MEH ElSayed - Expert Opinion on Drug Delivery, 2022 - Taylor & Francis
Introduction Numerous formulation technologies have been developed to overcome
challenges of oral peptide delivery. Understanding the advantages and limitations of each …
challenges of oral peptide delivery. Understanding the advantages and limitations of each …
Protecting bactofencin A to enable its antimicrobial activity using mesoporous matrices
E Durack, S Mallen, PM O'Connor, MC Rea… - International journal of …, 2019 - Elsevier
There is huge global concern surrounding the emergence of antimicrobial resistant bacteria
and this is resulting in an inability to treat infectious diseases. This is due to a lack of new …
and this is resulting in an inability to treat infectious diseases. This is due to a lack of new …