Oral delivery of biologics for precision medicine

M Durán‐Lobato, Z Niu, MJ Alonso - Advanced Materials, 2020 - Wiley Online Library
The emerging field of precision medicine is rapidly growing, fostered by the advances in
genome mapping and molecular diagnosis. In general, the translation of these advances …

Local delivery of macromolecules to treat diseases associated with the colon

A Bak, M Ashford, DJ Brayden - Advanced drug delivery reviews, 2018 - Elsevier
Current treatments for intestinal diseases including inflammatory bowel diseases, irritable
bowel syndrome, and colonic bacterial infections are typically small molecule oral dosage …

Nanocomposite systems for precise oral delivery of drugs and biologics

V Andretto, A Rosso, S Briançon, G Lollo - Drug delivery and translational …, 2021 - Springer
Oral delivery is considered the favoured route of administration for both local and systemic
delivery of active molecules. Formulation of drugs in conventional systems and …

[HTML][HTML] Comparison of the effects of the intestinal permeation enhancers, SNAC and sodium caprate (C10): Isolated rat intestinal mucosae and sacs

C Twarog, F McCartney, SM Harrison, B Illel… - European Journal of …, 2021 - Elsevier
SNAC and C 10 are intestinal permeation enhancers (PEs) used in formulations of peptides
for oral delivery in clinical trials. Our aims were to compare their:(i) mechanism of action in …

Spatiotemporally controlled calcitonin delivery: Long-term and targeted therapy of skeletal diseases

P Yu, Y Liu, J Xie, J Li - Journal of Controlled Release, 2021 - Elsevier
Bone is a connective tissue that support the entire body and protect the internal organs.
However, there are great challenges on curing intractable skeletal diseases such as …

Application or function of citric acid in drug delivery platforms

M Pooresmaeil, S Javanbakht… - Medicinal Research …, 2022 - Wiley Online Library
Nontoxic materials with natural origin are promising materials in the designing and
preparation of the new drug delivery systems (DDSs). Today's, citric acid (CA) has attracted …

[HTML][HTML] Calcitonin: A useful old friend

A Srinivasan, FK Wong, D Karponis - Journal of musculoskeletal & …, 2020 - ncbi.nlm.nih.gov
Calcitonin regulates blood calcium levels and possesses certain clinically useful anti-
fracture properties. Specifically, it reduces vertebral fractures in postmenopausal …

Mesoporous matrices for the delivery of the broad spectrum bacteriocin, nisin A

J Flynn, S Mallen, E Durack, PM O'Connor… - Journal of colloid and …, 2019 - Elsevier
Mesoporous matrices of different pore size and chemical composition were explored as
potential delivery matrices for the broad spectrum bacteriocin, nisin A. The adsorption of …

Progress and limitations of oral peptide delivery as a potentially transformative therapy

H Tran, MEH ElSayed - Expert Opinion on Drug Delivery, 2022 - Taylor & Francis
Introduction Numerous formulation technologies have been developed to overcome
challenges of oral peptide delivery. Understanding the advantages and limitations of each …

Protecting bactofencin A to enable its antimicrobial activity using mesoporous matrices

E Durack, S Mallen, PM O'Connor, MC Rea… - International journal of …, 2019 - Elsevier
There is huge global concern surrounding the emergence of antimicrobial resistant bacteria
and this is resulting in an inability to treat infectious diseases. This is due to a lack of new …