In vitro selection of aptamers and their applications
MC DeRosa, A Lin, P Mallikaratchy… - Nature Reviews …, 2023 - nature.com
The introduction of the in vitro evolution method known as SELEX (systematic evolution of
ligands by exponential enrichment) more than 30 years ago led to the conception of …
ligands by exponential enrichment) more than 30 years ago led to the conception of …
Advances and challenges in small‐molecule DNA aptamer isolation, characterization, and sensor development
Aptamers are short oligonucleotides isolated in vitro from randomized libraries that can bind
to specific molecules with high affinity, and offer a number of advantages relative to …
to specific molecules with high affinity, and offer a number of advantages relative to …
Computational tools for aptamer identification and optimization
D Sun, M Sun, J Zhang, X Lin, Y Zhang, F Lin… - TrAC Trends in …, 2022 - Elsevier
Aptamers are single-stranded DNA or RNA oligonucleotides that can selectively bind to a
specific target. They are generally obtained by SELEX, but the procedure is challenging and …
specific target. They are generally obtained by SELEX, but the procedure is challenging and …
Modified nucleic acid aptamers: development, characterization, and biological applications
Aptamers are single-stranded oligonucleotides that bind to their targets via specific structural
interactions. To improve the properties and performance of aptamers, modified nucleotides …
interactions. To improve the properties and performance of aptamers, modified nucleotides …
Design and prediction of aptamers assisted by in silico methods
SJ Lee, J Cho, BH Lee, D Hwang, JW Park - Biomedicines, 2023 - mdpi.com
An aptamer is a single-stranded DNA or RNA that binds to a specific target with high binding
affinity. Aptamers are developed through the process of systematic evolution of ligands by …
affinity. Aptamers are developed through the process of systematic evolution of ligands by …
[Retracted] MicroRNA‐133b Inhibition Restores EGFR Expression and Accelerates Diabetes‐Impaired Wound Healing
H Zhong, J Qian, Z Xiao, Y Chen, X He… - Oxidative Medicine …, 2021 - Wiley Online Library
Diabetic foot ulcers (DFUs) are caused by impairments in peripheral blood vessel
angiogenesis and represent a great clinical challenge. Although various innovative …
angiogenesis and represent a great clinical challenge. Although various innovative …
On the move-sensitive fluorescent aptassay on board catalytic micromotors for the determination of interleukin-6 in ultra-low serum volumes for neonatal sepsis …
J Gordón, L Arruza, MD Ibáñez, M Moreno-Guzmán… - ACS …, 2022 - ACS Publications
A graphene oxide/nickel/platinum nanoparticle micromotor (MM)-based fluorescent
aptassay is proposed to determine interleukin-6 (IL-6) in serum samples from low-birth …
aptassay is proposed to determine interleukin-6 (IL-6) in serum samples from low-birth …
Nucleic acid aptamers as aptasensors for plant biology
S Tungsirisurp, R O'Reilly, R Napier - Trends in Plant Science, 2023 - cell.com
Our knowledge of cell-and tissue-specific quantification of phytohormones is heavily reliant
on laborious mass spectrometry techniques. Genetically encoded biosensors have allowed …
on laborious mass spectrometry techniques. Genetically encoded biosensors have allowed …
Implementation of high-throughput sequencing (HTS) in aptamer selection technology
N Komarova, D Barkova, A Kuznetsov - International journal of molecular …, 2020 - mdpi.com
Aptamers are nucleic acid ligands that bind specifically to a target of interest. Aptamers have
gained in popularity due to their high potential for different applications in analysis …
gained in popularity due to their high potential for different applications in analysis …
Generating experimentally unrelated target molecule-binding highly functionalized nucleic-acid polymers using machine learning
In vitro selection queries large combinatorial libraries for sequence-defined polymers with
target binding and reaction catalysis activity. While the total sequence space of these …
target binding and reaction catalysis activity. While the total sequence space of these …