Background Risk stratification or progression in prostate cancer is performed with the
support of clinical-pathological data such as the sum of the Gleason score and serum levels …

Advances in RNA-sequencing technologies have led to the development of intriguing
experimental setups, a massive accumulation of data, and high demand for tools to analyze …

Hepatocellular carcinoma (HCC) is one of the most common malignant tumors with high
morbidity and mortality. Therefore, it is very important to find potential biomarkers that can …

Accumulating evidence has indicated that pre-mRNA splicing plays critical roles in a variety
of physiological processes, including development of multiple diseases. In particular …

Background Transcription, metabolism and DNA damage response are tightly regulated to
preserve the genomic integrity, and O-GlcNAc transferase (OGT) is positioned to connect the …

Abstract Treatment-naïve small cell lung cancer (SCLC) is typically susceptible to standard-
of-care chemotherapy consisting of cisplatin and etoposide recently combined with PD-L1 …

Highlights•Modulation of pre-mRNA splicing is an effective alternative to the direct targeting
of proteins.•Insight into pre-mRNA splicing biology offers practical targeted strategies to …

Co-targeting of O-GlcNAc transferase (OGT) and the transcriptional kinase cyclin-dependent
kinase 9 (CDK9) is toxic to prostate cancer cells. As OGT is an essential glycosyltransferase …

Purpose Prostate cancer (PC) is successfully treated with anti-androgens; however, a
significant proportion of patients develop resistance against this therapy. Anti-androgen …

Continued exploration of the androgen receptor (AR) is crucial, as it plays pivotal roles in
diverse diseases such as prostate cancer (PCa), serving as a significant therapeutic focus …