The critical role of the branched chain amino acids (BCAAs) catabolism-regulating enzymes, branched-chain aminotransferase (BCAT) and branched-chain α-keto …
A Dimou, V Tsimihodimos, E Bairaktari - International Journal of …, 2022 - mdpi.com
Branched chain amino acids (BCAAs), leucine, isoleucine and valine, are essential amino
acids widely studied for their crucial role in the regulation of protein synthesis mainly through …
acids widely studied for their crucial role in the regulation of protein synthesis mainly through …
The two sides of creatine in cancer
L Zhang, P Bu - Trends in cell biology, 2022 - cell.com
Creatine is a nitrogen-containing organic acid naturally existing in mammals. It can be
converted into phosphocreatine to provide energy for muscle and nerve tissues. Creatine …
converted into phosphocreatine to provide energy for muscle and nerve tissues. Creatine …
The gut microbiota influences skeletal muscle mass and function in mice
S Lahiri, H Kim, I Garcia-Perez, MM Reza… - Science translational …, 2019 - science.org
The functional interactions between the gut microbiota and the host are important for host
physiology, homeostasis, and sustained health. We compared the skeletal muscle of germ …
physiology, homeostasis, and sustained health. We compared the skeletal muscle of germ …
Characterization of anthropometric changes that occur during neoadjuvant therapy for potentially resectable pancreatic cancer
AB Cooper, R Slack, D Fogelman, HM Holmes… - Annals of surgical …, 2015 - Springer
Background Little is known about changes in body composition that may occur during
neoadjuvant therapy for pancreatic cancer. This study was designed to characterize these …
neoadjuvant therapy for pancreatic cancer. This study was designed to characterize these …
Creatine uptake regulates CD8 T cell antitumor immunity
T cells demand massive energy to combat cancer; however, the metabolic regulators
controlling antitumor T cell immunity have just begun to be unveiled. When studying nutrient …
controlling antitumor T cell immunity have just begun to be unveiled. When studying nutrient …
Fenofibrate prevents skeletal muscle loss in mice with lung cancer
MD Goncalves, SK Hwang, C Pauli… - Proceedings of the …, 2018 - National Acad Sciences
The cancer anorexia cachexia syndrome is a systemic metabolic disorder characterized by
the catabolism of stored nutrients in skeletal muscle and adipose tissue that is particularly …
the catabolism of stored nutrients in skeletal muscle and adipose tissue that is particularly …
Uric acid and xanthine oxidase in heart failure—Emerging data and therapeutic implications
W Doehner, EA Jankowska, J Springer… - International journal of …, 2016 - Elsevier
The role of hyperuricaemia as cardiovascular risk factor has exhaustingly been debated for
decades. While the association of elevated uric acid (UA) levels with increased mortality risk …
decades. While the association of elevated uric acid (UA) levels with increased mortality risk …
Muscle wasting in cancer: the role of mitochondria
JM Argilés, FJ López-Soriano… - Current Opinion in …, 2015 - journals.lww.com
An alteration of energy balance is the immediate cause of cachexia. Both alterations in
energy intake and expenditure are responsible for the wasting syndrome associated with …
energy intake and expenditure are responsible for the wasting syndrome associated with …
Branched-chain amino acids can predict mortality in ICU sepsis patients
Sepsis biomarkers and potential therapeutic targets are urgently needed. With proton
nuclear magnetic resonance (1H NMR) spectroscopy, several metabolites can be assessed …
nuclear magnetic resonance (1H NMR) spectroscopy, several metabolites can be assessed …
The potential therapeutic effects of creatine supplementation on body composition and muscle function in cancer
Low muscle mass in individuals with cancer has a profound impact on quality of life and
independence and is associated with greater treatment toxicity and poorer prognosis …
independence and is associated with greater treatment toxicity and poorer prognosis …