The critical role of the branched chain amino acids (BCAAs) catabolism-regulating enzymes, branched-chain aminotransferase (BCAT) and branched-chain α-keto …

A Dimou, V Tsimihodimos, E Bairaktari - International Journal of …, 2022 - mdpi.com
Branched chain amino acids (BCAAs), leucine, isoleucine and valine, are essential amino
acids widely studied for their crucial role in the regulation of protein synthesis mainly through …

The two sides of creatine in cancer

L Zhang, P Bu - Trends in cell biology, 2022 - cell.com
Creatine is a nitrogen-containing organic acid naturally existing in mammals. It can be
converted into phosphocreatine to provide energy for muscle and nerve tissues. Creatine …

The gut microbiota influences skeletal muscle mass and function in mice

S Lahiri, H Kim, I Garcia-Perez, MM Reza… - Science translational …, 2019 - science.org
The functional interactions between the gut microbiota and the host are important for host
physiology, homeostasis, and sustained health. We compared the skeletal muscle of germ …

Characterization of anthropometric changes that occur during neoadjuvant therapy for potentially resectable pancreatic cancer

AB Cooper, R Slack, D Fogelman, HM Holmes… - Annals of surgical …, 2015 - Springer
Background Little is known about changes in body composition that may occur during
neoadjuvant therapy for pancreatic cancer. This study was designed to characterize these …

Creatine uptake regulates CD8 T cell antitumor immunity

S Di Biase, X Ma, X Wang, J Yu, YC Wang… - Journal of Experimental …, 2019 - rupress.org
T cells demand massive energy to combat cancer; however, the metabolic regulators
controlling antitumor T cell immunity have just begun to be unveiled. When studying nutrient …

Fenofibrate prevents skeletal muscle loss in mice with lung cancer

MD Goncalves, SK Hwang, C Pauli… - Proceedings of the …, 2018 - National Acad Sciences
The cancer anorexia cachexia syndrome is a systemic metabolic disorder characterized by
the catabolism of stored nutrients in skeletal muscle and adipose tissue that is particularly …

Uric acid and xanthine oxidase in heart failure—Emerging data and therapeutic implications

W Doehner, EA Jankowska, J Springer… - International journal of …, 2016 - Elsevier
The role of hyperuricaemia as cardiovascular risk factor has exhaustingly been debated for
decades. While the association of elevated uric acid (UA) levels with increased mortality risk …

Muscle wasting in cancer: the role of mitochondria

JM Argilés, FJ López-Soriano… - Current Opinion in …, 2015 - journals.lww.com
An alteration of energy balance is the immediate cause of cachexia. Both alterations in
energy intake and expenditure are responsible for the wasting syndrome associated with …

Branched-chain amino acids can predict mortality in ICU sepsis patients

AC Reisinger, F Posch, G Hackl, G Marsche, H Sourij… - Nutrients, 2021 - mdpi.com
Sepsis biomarkers and potential therapeutic targets are urgently needed. With proton
nuclear magnetic resonance (1H NMR) spectroscopy, several metabolites can be assessed …

The potential therapeutic effects of creatine supplementation on body composition and muscle function in cancer

CM Fairman, KL Kendall, NH Hart, DR Taaffe… - Critical Reviews in …, 2019 - Elsevier
Low muscle mass in individuals with cancer has a profound impact on quality of life and
independence and is associated with greater treatment toxicity and poorer prognosis …