BMI-1, a promising therapeutic target for human cancer

MC Wang, CL Li, J Cui, M Jiao, T Wu… - Oncology …, 2015 - spandidos-publications.com
BMI-1 oncogene is a member of the polycomb-group gene family and a transcriptional
repressor. Overexpression of BMI-1 has been identified in various human cancer tissues …

MicroRNA-155 and cancer metastasis: Regulation of invasion, migration, and epithelial-to-mesenchymal transition

H Moutabian, UK Radi, AY Saleman, M Adil… - … -Research and Practice, 2023 - Elsevier
Among the leading causes of death globally has been cancer. Nearly 90% of all cancer-
related fatalities are attributed to metastasis, which is the growing of additional malignant …

Bmi-1-induced miR-27a and miR-155 promote tumor metastasis and chemoresistance by targeting RKIP in gastric cancer

Y Li, Z Tian, Y Tan, G Lian, S Chen, S Chen, J Li, X Li… - Molecular Cancer, 2020 - Springer
Background We previously reported an inverse relationship between B cell-specific Moloney
murine leukemia virus integration site 1 (Bmi-1) and Raf kinase inhibitory protein (RKIP) …

LncRNA CASC9 suppressed the apoptosis of gastric cancer cells through regulating BMI1

J Fang, W Chen, XL Meng - Pathology & Oncology Research, 2020 - Springer
Long noncoding RNAs (lncRNAs) play important roles in regulating the apoptosis of gastric
cancer (GC) cells. This study aims to investigate the underlying mechanism of lncRNA …

MAPK/c-Jun signaling pathway contributes to the upregulation of the anti-apoptotic proteins Bcl-2 and Bcl-xL induced by Epstein-Barr virus-encoded BARF1 in gastric …

Y Zhang, M Xu, X Zhang, F Chu… - Oncology …, 2018 - spandidos-publications.com
BARF1, encoded by Epstein-Barr virus (EBV), has been hypothesized to function as an
oncogene, which was expressed in gastric carcinoma cells. Additionally, it has been …

Bmi-1 promotes the proliferation, migration and invasion, and inhibits cell apoptosis of human retinoblastoma cells via RKIP

Q Li, T Fu, N Wei, Q Wang, X Zhang - Scientific Reports, 2024 - nature.com
Retinoblastoma is one of the most common ocular malignancies in children. Bmi-1, a
member of the Polycomb group family of transcriptional repressors, is expressed in a variety …

[HTML][HTML] Expression of Bmi-1 and PAI-1 in esophageal squamous cell carcinoma

Y Zhang, YL Zhang, HM Chen, HW Pu… - World Journal of …, 2014 - ncbi.nlm.nih.gov
AIM: To determine the correlation between invasiveness, migration and prognosis in
esophageal squamous cell carcinoma (ESCC) and expression of the B-cell-specific …

Inverse association between Bmi-1 and RKIP affecting clinical outcome of gastric cancer and revealing the potential molecular mechanisms underlying tumor …

Y Chen, G Lian, G Ou, K Yang, J Chen, H Li, S Chen… - Gastric Cancer, 2016 - Springer
Background B-cell-specific Moloney murine leukemia virus integration site 1 (Bmi-1) and Raf
kinase inhibitory protein (RKIP) are involved in cancer metastasis and chemotherapeutic …

[PDF][PDF] Up-regulation of miR-203 inhibits the growth of cervical cancer cells by inducing cell cycle arrest and apoptosis

S Zhao, L Yan, Z Zhao, F Rong - Eur J Gynaecol Oncol, 2019 - article.imrpress.com
Summary Purpose: MicroRNA-203 (miR-203) had previously been proved to alter in various
cancers. In the present research, the authors attempted to assess the roles of miR-203 in …

miR-218 inhibits gastric tumorigenesis through regulating Bmi-1/Akt signaling pathway

Y Wu, S Tian, Y Chen, M Ji, Y Qu, P Hou - Pathology-Research and …, 2019 - Elsevier
Background Previous studies indicated that miR-218 was deregulated in gastric cancer
patients and correlated with tumor invasion and prognosis. The aim of this study was to …