Cis-regulatory elements: molecular mechanisms and evolutionary processes underlying divergence
PJ Wittkopp, G Kalay - Nature Reviews Genetics, 2012 - nature.com
Cis-regulatory sequences, such as enhancers and promoters, control development and
physiology by regulating gene expression. Mutations that affect the function of these …
physiology by regulating gene expression. Mutations that affect the function of these …
Tuning gene expression to changing environments: from rapid responses to evolutionary adaptation
Organisms are constantly exposed to a wide range of environmental changes, including
both short-term changes during their lifetime and longer-term changes across generations …
both short-term changes during their lifetime and longer-term changes across generations …
[HTML][HTML] Comparative Hi-C reveals that CTCF underlies evolution of chromosomal domain architecture
Topological domains are key architectural building blocks of chromosomes, but their
functional importance and evolutionary dynamics are not well defined. We performed …
functional importance and evolutionary dynamics are not well defined. We performed …
[HTML][HTML] An integrated encyclopedia of DNA elements in the human genome
ENCODE Project Consortium - Nature, 2012 - ncbi.nlm.nih.gov
The human genome encodes the blueprint of life, but the function of the vast majority of its
nearly three billion bases is unknown. The Encyclopedia of DNA Elements (ENCODE) …
nearly three billion bases is unknown. The Encyclopedia of DNA Elements (ENCODE) …
Comparison of the transcriptional landscapes between human and mouse tissues
Although the similarities between humans and mice are typically highlighted,
morphologically and genetically, there are many differences. To better understand these two …
morphologically and genetically, there are many differences. To better understand these two …
[HTML][HTML] High-resolution mapping reveals a conserved, widespread, dynamic mRNA methylation program in yeast meiosis
Summary N 6-methyladenosine (m 6 A) is the most ubiquitous mRNA base modification, but
little is known about its precise location, temporal dynamics, and regulation. Here, we …
little is known about its precise location, temporal dynamics, and regulation. Here, we …
A comparative encyclopedia of DNA elements in the mouse genome
The laboratory mouse shares the majority of its protein-coding genes with humans, making it
the premier model organism in biomedical research, yet the two mammals differ in …
the premier model organism in biomedical research, yet the two mammals differ in …
[HTML][HTML] Waves of retrotransposon expansion remodel genome organization and CTCF binding in multiple mammalian lineages
CTCF-binding locations represent regulatory sequences that are highly constrained over the
course of evolution. To gain insight into how these DNA elements are conserved and spread …
course of evolution. To gain insight into how these DNA elements are conserved and spread …
A recently evolved transcriptional network controls biofilm development in Candida albicans
A biofilm is an organized, resilient group of microbes in which individual cells acquire
properties, such as drug resistance, that are distinct from those observed in suspension …
properties, such as drug resistance, that are distinct from those observed in suspension …
Transposable elements have rewired the core regulatory network of human embryonic stem cells
Detection of new genomic control elements is critical in understanding transcriptional
regulatory networks in their entirety. We studied the genome-wide binding locations of three …
regulatory networks in their entirety. We studied the genome-wide binding locations of three …