In addition to hearing loss, damage to the cochlea can lead to gain of function pathologies
such as hyperacusis. It has been proposed that painful hyperacusis, noxacusis, may be …

Background Keratitis ichthyosis deafness (KID) syndrome is a rare disorder caused by
hemichannel (HC) activating gain-of-function mutations in the GJB2 gene encoding …

Connexin (Cx) hemichannels (HCs) are large pore hexameric structures that allow the
exchange of ions, metabolites and a variety of other molecules between the cell cytoplasm …

In a previous report, keratinocytes were shown to share their gene expression profile with
surrounding Langerhans cells (LCs), influencing LC biology. Here, we investigated whether …

Cells around epithelial wounds must first become aware of the wound's presence in order to
initiate the wound-healing process. An initial response to an epithelial wound is an increase …

Recent work demonstrates that epidermal keratinocytes are critical for normal touch
sensation. However, it is unknown if keratinocytes contribute to touch evoked pain and …

Multimodal microscopy combines multiple non-linear techniques that take advantage of
different optical processes to generate contrast and increase the amount of information that …

In this chapter, we provide detailed instructions to perform quantitative reflectance imaging
in a mouse model of a rare epidermal disorder caused by hyperactive connexin 26 …

Changes in cytosolic Ca2+ concentration ([Ca2+] c) serve as an almost ubiquitous signal in
organisms across the four kingdoms of Eukaryota, and perhaps in some prokaryotes of …