Pediatric low-grade glioma in the era of molecular diagnostics
Low grade gliomas are the most frequent brain tumors in children and encompass a
spectrum of histologic entities which are currently assigned World Health Organisation …
spectrum of histologic entities which are currently assigned World Health Organisation …
BRAF mutations and the utility of RAF and MEK inhibitors in primary brain tumors
KC Schreck, SA Grossman, CA Pratilas - Cancers, 2019 - mdpi.com
BRAF mutations have been identified as targetable, oncogenic mutations in many cancers.
Given the paucity of treatments for primary brain tumors and the poor prognosis associated …
Given the paucity of treatments for primary brain tumors and the poor prognosis associated …
Integrated molecular and clinical analysis of 1,000 pediatric low-grade gliomas
Pediatric low-grade gliomas (pLGG) are frequently driven by genetic alterations in the RAS-
mitogen-activated protein kinase (RAS/MAPK) pathway yet show unexplained variability in …
mitogen-activated protein kinase (RAS/MAPK) pathway yet show unexplained variability in …
Alterations in ALK/ROS1/NTRK/MET drive a group of infantile hemispheric gliomas
AS Guerreiro Stucklin, S Ryall, K Fukuoka… - Nature …, 2019 - nature.com
Infant gliomas have paradoxical clinical behavior compared to those in children and adults:
low-grade tumors have a higher mortality rate, while high-grade tumors have a better …
low-grade tumors have a higher mortality rate, while high-grade tumors have a better …
[HTML][HTML] Alterations in ALK/ROS1/NTRK/MET drive a group of infantile hemispheric gliomas
ASG Stucklin, S Ryall, K Fukuoka… - Nature …, 2019 - ncbi.nlm.nih.gov
Infant gliomas have paradoxical clinical behavior compared to those in children and adults:
low-grade tumors have a higher mortality rate, while high-grade tumors have a better …
low-grade tumors have a higher mortality rate, while high-grade tumors have a better …
Implications of BRAF V600E mutation in gliomas: Molecular considerations, prognostic value and treatment evolution
V Di Nunno, L Gatto, A Tosoni, S Bartolini… - Frontiers in …, 2023 - frontiersin.org
Gliomas are molecularly heterogeneous brain tumors responsible for the most years of life
lost by any cancer. High-grade gliomas have a poor prognosis and despite multimodal …
lost by any cancer. High-grade gliomas have a poor prognosis and despite multimodal …
Treatment of pediatric low-grade gliomas
SF Sait, AM Giantini-Larsen, KR Tringale… - Current neurology and …, 2023 - Springer
Abstract Purpose of Review Pediatric low-grade gliomas and glioneuronal tumors (pLGG)
account for approximately 30% of pediatric CNS neoplasms, encompassing a …
account for approximately 30% of pediatric CNS neoplasms, encompassing a …
Mucoepidermoid carcinoma may be devoid of squamoid cells by immunohistochemistry: expanding the histologic and immunohistochemical spectrum of MAML2 …
Mucoepidermoid carcinoma (MEC) is historically defined by a mix of squamoid,
intermediate, and mucous cells, but we have recently encountered several cases lacking …
intermediate, and mucous cells, but we have recently encountered several cases lacking …
[HTML][HTML] Pediatric low-grade glioma: Targeted therapeutics and clinical trials in the molecular era
N Manoharan, KX Liu, S Mueller, DA Haas-Kogan… - Neoplasia, 2023 - Elsevier
Abstract pLGGs are a group of tumors for which the era of molecular diagnostics has truly
shifted treatment paradigms and patient care. The discovery that this group of tumors is …
shifted treatment paradigms and patient care. The discovery that this group of tumors is …
A pediatric brain tumor atlas of genes deregulated by somatic genomic rearrangement
Y Zhang, F Chen, LA Donehower, ME Scheurer… - Nature …, 2021 - nature.com
The global impact of somatic structural variants (SSVs) on gene expression in pediatric brain
tumors has not been thoroughly characterised. Here, using whole-genome and RNA …
tumors has not been thoroughly characterised. Here, using whole-genome and RNA …