Uncovering the mechanisms of Acinetobacter baumannii virulence

CM Harding, SW Hennon, MF Feldman - Nature Reviews Microbiology, 2018 - nature.com
Acinetobacter baumannii is a nosocomial pathogen that causes ventilator-associated as
well as bloodstream infections in critically ill patients, and the spread of multidrug-resistant …

Emerging facets of prokaryotic glycosylation

C Schäffer, P Messner - FEMS microbiology reviews, 2017 - academic.oup.com
Glycosylation of proteins is one of the most prevalent post-translational modifications
occurring in nature, with a wide repertoire of biological implications. Pathways for the main …

Diversity and Function of Capsular Polysaccharide in Acinetobacter baumannii

JK Singh, FG Adams, MH Brown - Frontiers in microbiology, 2019 - frontiersin.org
The Gram-negative opportunistic bacterium Acinetobacter baumannii is a significant cause
of hospital-borne infections worldwide. Alarmingly, the rapid development of antimicrobial …

A promising bioconjugate vaccine against hypervirulent Klebsiella pneumoniae

MF Feldman, AE Mayer Bridwell… - Proceedings of the …, 2019 - National Acad Sciences
Hypervirulent Klebsiella pneumoniae (hv Kp) is globally disseminating as a community-
acquired pathogen causing life-threatening infections in healthy individuals. The fact that a …

Pathogenic Acinetobacter: from the cell surface to infinity and beyond

BS Weber, CM Harding, MF Feldman - Journal of bacteriology, 2016 - Am Soc Microbiol
The genus Acinetobacter encompasses multiple nosocomial opportunistic pathogens that
are of increasing worldwide relevance because of their ability to survive exposure to various …

Acinetobacter baumannii: Envelope Determinants That Control Drug Resistance, Virulence, and Surface Variability

E Geisinger, W Huo, J Hernandez-Bird… - Annual review of …, 2019 - annualreviews.org
Acinetobacter baumannii has emerged as an important nosocomial pathogen, particularly
for patients in intensive care units and with invasive indwelling devices. The most recent …

Capsular polysaccharide inhibits vaccine-induced O-antigen antibody binding and function across both classical and hypervirulent K2: O1 strains of Klebsiella …

PL Wantuch, CJ Knoot, LS Robinson… - PLoS …, 2023 - journals.plos.org
Klebsiella pneumoniae presents as two circulating pathotypes: classical K. pneumoniae (c
Kp) and hypervirulent K. pneumoniae (hv Kp). Classical isolates are considered urgent …

Glycoengineering bioconjugate vaccines, therapeutics, and diagnostics in E. coli

CM Harding, MF Feldman - Glycobiology, 2019 - academic.oup.com
The first, general glycosylation pathway in bacteria, the N-linked glycosylation system of
Campylobacter jejuni, was discovered two decades ago. Since then, many diverse …

Sweet talk: protein glycosylation in bacterial interaction with the host

Q Lu, S Li, F Shao - Trends in Microbiology, 2015 - cell.com
Pathogenic bacteria encode virulent glycosyltransferases that conjugate various glycans
onto substrate proteins via the N-or O-linkage. The HMW system in nontypeable …

A platform for glycoengineering a polyvalent pneumococcal bioconjugate vaccine using E. coli as a host

CM Harding, MA Nasr, NE Scott… - Nature …, 2019 - nature.com
Chemical synthesis of conjugate vaccines, consisting of a polysaccharide linked to a protein,
can be technically challenging, and in vivo bacterial conjugations (bioconjugations) have …