Abstract Treatment of tuberculosis (TB) has been a therapeutic challenge because of not
only the naturally high resistance level of Mycobacterium tuberculosis to antibiotics but also …

Isoniazid (INH) is one of the most active compounds used to treat tuberculosis (TB)
worldwide. In addition, INH has been used as a prophylactic drug for individuals with latent …

Robotic systems for synthetic chemistry are becoming more common, but they are
expensive, fixed to a narrow set of reactions, and must be used within a complex laboratory …

Knowledge of the molecular genetic basis of resistance to antituberculous agents has
advanced rapidly since we reviewed this topic 3 years ago. Virtually all isolates resistant to …

Page 1 Catalogue of mutations in Mycobacterium tuberculosis complex and their
association with drug resistance Second edition Page 2 Page 3 Catalogue of mutations in …

Oxidative stress, through the production of reactive oxygen species, is a natural
consequence of aerobic metabolism. Escherichia coli has several major regulators activated …

The anaerobic protozoa Giardia duodenalis, Trichomonas vaginalis, and Entamoeba
histolytica infect up to a billion people each year. G. duodenalis and E. histolytica are …

For decades after its introduction, the mechanisms of action of the front‐line antituberculosis
therapeutic agent isoniazid (INH) remained unclear. Recent developments have shown that …

Tuberculosis (TB) has become a curable disease, thanks to the discovery of antibiotics.
However, it has remained one of the most difficult infections to treat. Most current TB …

Drug-resistant tuberculosis (TB) is estimated to cause 13% of all antimicrobial resistance-
attributable deaths worldwide and is driven by both ongoing resistance acquisition and …