Although originally discovered as neuronal growth cone-collapsing factors, repulsive
guidance molecules (RGMs) are now known as key players in many fundamental …

The study of human 3D cell culture models not only bridges the gap between traditional 2D
in vitro experiments and in vivo animal models, it also addresses processes that cannot be …

To date, the development of disease-modifying therapies for Alzheimer's disease (AD) has
largely focused on the removal of amyloid beta Aβ fragments from the CNS. Proteomic …

Axon regeneration is an energy-demanding process that requires active mitochondrial
transport. In contrast to the central nervous system (CNS), axonal mitochondrial transport in …

A rapid proinflammatory response after peripheral nerve injury is required for clearance of
tissue debris (Wallerian degeneration) and effective regeneration. Unlike the CNS, this …

Adult mammalian injured axons regenerate over short-distance in the peripheral nervous
system (PNS) while the axons in the central nervous system (CNS) are unable to regrow …

Treating neuropathic pain is challenging and novel non–opioid-based medicines are
needed. Using unbiased receptomics, transcriptomic analyses, immunofluorescence, and in …

Tubular cell necrosis is a key histological feature of acute kidney injury (AKI). Necroptosis is
a type of programed necrosis, which is executed by mixed lineage kinase domain-like …

Peripheral nerves regenerate successfully; however, clinical outcome after injury is poor. We
demonstrated that low-dose ionizing radiation (LDIR) promoted axon regeneration and …

Bone morphogenetic proteins (BMPs) make up a family of morphogens that are critical for
patterning, development, and function of the central and peripheral nervous system. Their …