Pathophysiology of eosinophilic esophagitis

KM O'Shea, SS Aceves, ES Dellon, SK Gupta… - Gastroenterology, 2018 - Elsevier
Eosinophilic esophagitis is an emerging disease that is distinguished from
gastroesophageal reflux disease by the expression of a unique esophageal transcriptome …

Pediatric and adult eosinophilic esophagitis: similarities and differences

A Straumann, SS Aceves, C Blanchard, MH Collins… - Allergy, 2012 - Wiley Online Library
Early in the 1990s, several case series described adults suffering from dysphagia and
children with refractory reflux symptoms, both accompanied by an eosinophil‐predominant …

A phenotypic analysis shows that eosinophilic esophagitis is a progressive fibrostenotic disease

ES Dellon, HP Kim, SLW Sperry, DA Rybnicek… - Gastrointestinal …, 2014 - Elsevier
Background Phenotypes of eosinophilic esophagitis (EoE) are not well-characterized.
Objective To describe clinical features of patients with EoE with predefined phenotypes …

[HTML][HTML] Budesonide oral suspension improves symptomatic, endoscopic, and histologic parameters compared with placebo in patients with eosinophilic esophagitis

ES Dellon, DA Katzka, MH Collins, M Hamdani… - Gastroenterology, 2017 - Elsevier
Background & Aims Pharmacologic treatment of eosinophilic esophagitis (EoE) is limited to
off-label use of corticosteroids not optimized for esophageal delivery. We performed a …

Clinical guidance for the use of dupilumab in eosinophilic esophagitis: a yardstick

SS Aceves, ES Dellon, M Greenhawt, I Hirano… - Annals of Allergy …, 2023 - Elsevier
Abstract The Joint Task Force for the American Academy of Allergy Asthma Immunology and
American College of Allergy Asthma Immunology and the American Gastroenterology …

Efficacy of proton pump inhibitor therapy for eosinophilic oesophagitis in 630 patients: results from the EoE connect registry

EJ Laserna‐Mendieta, S Casabona… - Alimentary …, 2020 - Wiley Online Library
Summary Background Proton pump inhibitors (PPIs) are the most commonly used first‐line
therapy for patients with eosinophilic oesophagitis (EoE). However, many aspects related to …

Histopathologic features of eosinophilic esophagitis and eosinophilic gastrointestinal diseases

MH Collins - Gastroenterology Clinics, 2014 - gastro.theclinics.com
Eosinophilic esophagitis (EoE) is a chronic immune antigen-mediated disease (Box 1). 1–3
Patients who have EoE respond to antigen elimination, especially elimination of food …

Eosinophilic esophagitis: clinical, endoscopic, histologic and therapeutic differences and similarities between children and adults

P Visaggi, E Savarino, G Sciume… - Therapeutic …, 2021 - journals.sagepub.com
In the absence of secondary causes, eosinophilic esophagitis (EoE) is a chronic, local,
progressive, T-helper type 2 immune-mediated disorder characterized by symptoms of …

Type 2 inflammation in eosinophilic esophagitis: from pathophysiology to therapeutic targets

F Racca, G Pellegatta, G Cataldo, E Vespa… - Frontiers in …, 2022 - frontiersin.org
Eosinophilic esophagitis (EoE) is a chronic immune-mediated disease of the esophagus
characterized clinically by symptoms related to esophageal dysfunction and histologically by …

Mechanistic insights into eosinophilic esophagitis: therapies targeting pathophysiological mechanisms

S Massironi, G Mulinacci, C Gallo, A Elvevi, S Danese… - Cells, 2023 - mdpi.com
Eosinophilic esophagitis (EoE) is a chronic inflammatory disease characterized by
eosinophilic infiltration of the esophagus. It arises from a complex interplay of genetic …