Mitochondria are key cell organelles in that they are responsible for energy production and
control many processes from signalling to cell death. The function of the mitochondrial …

Generation, transformation, and utilization of organic molecules in support of cellular
differentiation, growth, and maintenance are basic tenets that define life. In eukaryotes …

Neuroinflammatory response is primarily a protective mechanism in the brain. However,
excessive and chronic inflammatory responses can lead to deleterious effects involving …

Neurodegenerative diseases represent some of the most devastating neurological
disorders, characterized by progressive loss of the structure and function of neurons. Current …

Mitochondrial dysfunction is a common feature in neurodegeneration and aging. We identify
mitochondrial dysfunction in xeroderma pigmentosum group A (XPA), a nucleotide excision …

Biological tissues require oxygen to meet their energetic demands. However, the
consumption of oxygen also results in the generation of free radicals that may have …

Parkinson's disease is a pervasive, ageing-related neurodegenerative disease the cardinal
motor symptoms of which reflect the loss of a small group of neurons, the dopaminergic …

Redox-dependent processes influence most cellular functions, such as differentiation,
proliferation, and apoptosis. Mitochondria are at the center of these processes, as …

Evolution favored individuals with superior cognitive and physical abilities under conditions
of limited food sources, and brain function can therefore be optimized by intermittent dietary …

Specific neuronal populations display high vulnerability to pathological processes in
Parkinson's disease (PD). The dorsal motor nucleus of the vagus nerve (DMnX) is a primary …