Astrocytic Chitinase‐3‐like protein 1 in neurological diseases: Potential roles and future perspectives

F Li, A Liu, M Zhao, L Luo - Journal of Neurochemistry, 2023 - Wiley Online Library
Abstract Chitinase‐3‐like protein 1 (CHI3L1) is a secreted glycoprotein characterized by its
ability to regulate multiple biological processes, such as the inflammatory response and …

[HTML][HTML] Neurofilament light chain in blood as a diagnostic and predictive biomarker for multiple sclerosis: A systematic review and meta-analysis

L Ning, B Wang - PLoS One, 2022 - journals.plos.org
Background Neurofilament light chain (NfL) in cerebrospinal fluid (CSF) is a biomarker of
multiple sclerosis (MS). However, CSF sampling is invasive and has limited the clinical …

[HTML][HTML] The translatability of multiple sclerosis animal models for biomarkers discovery and their clinical use

D Birmpili, I Charmarke Askar, K Bigaut… - International journal of …, 2022 - mdpi.com
Multiple Sclerosis (MS) is a chronic autoimmune disease affecting the central nervous
system which is characterized by demyelinating lesions and axonal damage. MS is a …

[HTML][HTML] The role of Tau beyond Alzheimer's disease: a narrative review

E Virgilio, F De Marchi, E Contaldi, U Dianzani… - Biomedicines, 2022 - mdpi.com
Nowadays, there is a need for reliable fluid biomarkers to improve differential diagnosis,
prognosis, and the prediction of treatment response, particularly in the management of …

[HTML][HTML] The multiple sclerosis prodrome: evidence to action

H Tremlett, KL Munger, N Makhani - Frontiers in Neurology, 2022 - frontiersin.org
A growing body of work points toward the existence of a clinically symptomatic prodromal
phase in multiple sclerosis (MS) that might span 5–10 years or more. A prodrome is an early …

[HTML][HTML] Identification and management of subclinical disease activity in early multiple sclerosis: a review

D Ontaneda, T Chitnis, K Rammohan, AZ Obeidat - Journal of Neurology, 2024 - Springer
Importance Early treatment initiation in multiple sclerosis (MS) is crucial in preventing
irreversible neurological damage and disability progression. The current assessment of …

[HTML][HTML] Synaptic dysfunction in multiple sclerosis: a red thread from inflammation to network disconnection

L Bellingacci, A Mancini, L Gaetani, A Tozzi… - International Journal of …, 2021 - mdpi.com
Multiple sclerosis (MS) has been clinically considered a chronic inflammatory disease of the
white matter; however, in the last decade growing evidence supported an important role of …

[HTML][HTML] Emerging biomarkers of multiple sclerosis in the blood and the CSF: a focus on neurofilaments and therapeutic considerations

T Biernacki, Z Kokas, D Sandi, J Füvesi… - International Journal of …, 2022 - mdpi.com
Introduction: Multiple Sclerosis (MS) is the most common immune-mediated chronic
neurodegenerative disease of the central nervous system (CNS) affecting young people …

[HTML][HTML] Potential biological contributers to the sex difference in multiple sclerosis progression

N Alvarez-Sanchez, SE Dunn - Frontiers in Immunology, 2023 - frontiersin.org
Multiple sclerosis (MS) is an immune-mediated disease that targets the myelin sheath of
central nervous system (CNS) neurons leading to axon injury, neuronal death, and …

[HTML][HTML] Serum-based biomarkers in neurodegeneration and multiple sclerosis

P LoPresti - Biomedicines, 2022 - mdpi.com
Multiple Sclerosis (MS) is a debilitating disease with typical onset between 20 and 40 years
of age, so the disability associated with this disease, unfortunately, occurs in the prime of life …