Cyclic guanosine 3', 5'-monophosphate (cGMP) mediates a wide spectrum of physiologic
processes in multiple cell types within the cardiovascular system. Dysfunctional signaling at …

In this review, we outline the current knowledge on the regulation of nitric oxide (NO)-
sensitive guanylyl cyclase (GC). Besides NO, the physiological activator that binds to the …

A MAJOR mechanism by which insulin stimulates glucose transport in muscle and fat is the
translocation of glucose transporters from an intracellular membrane pool to the cell …

ATRIAL natriuretic peptide (ANP) is a polypeptide hormone whose effects include the
induction of diuresis, natriuresis and vasorelaxation1. One of the earliest events following …

▪ Abstract Many biological functions of heme oxygenase (HO), such as cytoprotection
against oxidative stress, vasodilation, neurotransmission in the central or peripheral nervous …

Nitric Oxide and Cyclic GMP in Cell Signaling and Drug Development | New England Journal
of Medicine Skip to main content The New England Journal of Medicine homepage Advanced …

A wide spectrum of ligands, including hormones, autacoids, drugs and toxins, have cGMP as
their common mediator in eliciting diverse physiological responses. Signal transduction …

Despite widespread distribution in most mammalian cells, the role of soluble guanylate
cyclase has, until recently, been poorly defined, especially when compared with its more …

IN 1963, shortly after the discovery of cAMP (1–5), Ashman et al.(6) identified cyclic-GMP
(cGMP) in rat urine. Reports soon followed showing that various agents including …

Since the discoveries that have verified nitric oxide (NO) as an endogenously produced cell
signaling molecule, research surrounding its production and mechanisms of action have …