Unravelling the epigenetic impact: Oxidative stress and its role in male infertility-associated sperm dysfunction

G Sudhakaran, D Kesavan, K Kandaswamy… - Reproductive …, 2024 - Elsevier
Male infertility is a multifactorial condition influenced by epigenetic regulation, oxidative
stress, and mitochondrial dysfunction. Oxidative stress-induced damage leads to epigenetic …

Sperm DNA damage and its impact on male reproductive health: a critical review for clinicians, reproductive professionals and researchers

A Agarwal, MK Panner Selvam… - Expert review of …, 2019 - Taylor & Francis
Introduction: Sperm DNA damage is the major molecular cause of male infertility, which has
a negative effect on reproductive outcomes in couples. Sperm DNA damage originates …

Oxidative stress and its association with male infertility

A Agarwal, P Sengupta - Male infertility: contemporary clinical approaches …, 2020 - Springer
Reactive oxygen species (ROS) is one of the most common causatives of male infertility. At
normal physiological levels, ROS mediate essential physiological roles to ensure proper …

Sperm DNA fragmentation and male infertility

MK Panner Selvam, P Sengupta, A Agarwal - Genetics of Male Infertility: A …, 2020 - Springer
Sperm DNA fragmentation (SDF) is associated with male infertility, and it adversely affects
reproductive outcomes. Both chromatin integrity and protamination status determine the …

MitoQ ameliorates testicular damage induced by gamma irradiation in rats: modulation of mitochondrial apoptosis and steroidogenesis

AA Ibrahim, HM Karam, EA Shaaban, MM Safar… - Life sciences, 2019 - Elsevier
Aims The deleterious effect of gamma radiation on testicular tissue is a challenging problem
in nuclear medicine. This study investigated the potential radioprotective effect of mitoquinol …

Intrathecal nusinersen administration in adult spinal muscular atrophy patients with complex spinal anatomy

I Cordts, P Lingor, B Friedrich… - Therapeutic …, 2020 - journals.sagepub.com
Background: Intrathecal administration of nusinersen in adult spinal muscular atrophy (SMA)
patients presents challenges owing to severe scoliosis and previous spinal surgery with …

Radiation and male reproductive system: damage and protection

C Guo, Q Wang, P Shuai, T Wang, W Wu, Y Li… - Chemosphere, 2024 - Elsevier
Male fertility has been declining in recent decades, and a growing body of research points to
environmental and lifestyle factors as the cause. The widespread use of radiation …

Low-Dose Radiation Exposure with 56MnO2 Powder Changes Gene Expressions in the Testes and the Prostate in Rats

N Fujimoto, G Amantayeva, N Chaizhunussova… - International Journal of …, 2020 - mdpi.com
To investigate the biological effects of internal exposure of radioactive 56MnO2 powder, the
major radioisotope dust in the soil after atomic bomb explosions, on male reproductive …

Pelvic radiation-induced testicular damage: an experimental study at 1 Gray

SY Rakici, AI Guzel, L Tumkaya… - Systems biology in …, 2020 - Taylor & Francis
Therapeutic radiation of the pelvic region has been shown to cause damage to testicular
germ cells. In this study we aimed to evaluate the effects of a low therapeutic dose of 1 Gy on …

Impact of radiation on male fertility

S Srivasatav, J Mishra, P Keshari, S Verma… - Oxidative Stress and …, 2022 - Springer
In today's time, environmental aspects, lifestyle changes, and person's health coalesce to
form stupendous impact on the fertility. All of us are knowingly or unknowingly exposed to …