Background Polypharmacy and use of inappropriate medications have been linked to
increased risk of falls, hospitalizations, cognitive impairment, and death. The primary …

Background Inappropriate polypharmacy is a particular concern in older people and is
associated with negative health outcomes. Choosing the best interventions to improve …

Background Potentially inappropriate medications (PIM) for the older adults are those with
an unfavorable risk-benefit ratio when more effective and safe therapeutic alternatives are …

Interpreting results from deprescribing interventions to generate actionable evidence is
challenging owing to inconsistent and heterogeneous outcome definitions between studies …

Background Deprescribing can reduce the use of inappropriate or unnecessary medication;
however, the economic value of such interventions is uncertain. Objective This study seeks …

Purpose To conduct a systematic review of the economic impact of interventions intended at
optimizing medication use in older adults with multimorbidity and polypharmacy. Methods …

Objectives Several implementation strategies can reduce potentially inappropriate
medication (PIM) prescribing. Although use of PIMs has declined in recent years, it remains …

Background Polypharmacy is a major global problem. Evidence in primary care shows
deprescribing can be beneficial. Behaviour change theories such as the Theoretical …

Background Potentially inappropriate prescribing (PIP) is common in older adults and
known to be associated with polypharmacy and multimorbidity. Less is known about the …

BACKGROUND Inappropriate prescribing is a highly important problem, given the growing
aging multimorbid population with associated polypharmacy. An increasing number of …