Inflammasomes are multi‐protein complexes that assemble within the cytoplasm of
mammalian cells in response to pathogen‐associated molecular patterns (PAMPs) or …

The innate immune system serves as the body's initial defense, swiftly detecting danger via
pattern recognition receptors (PRRs). Among these, nucleotide-binding oligomerization …

Cigarette smoke (CS) is a major risk factor for chronic lung diseases and promotes activation
of pattern recognition receptors in the bronchial epithelium. NOD‐like receptor family, pyrin …

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Inflammasomes comprise a group of protein complexes with fundamental roles in the
induction of inflammation. Upon sensing stress factors, their assembly induces the activation …

The NLRP3 inflammasome is a critical component of the innate immune response. NLRP3
activation is a tightly controlled process involving an initial priming to express NLRP3, pro-IL …

Oxidative stress and the accompanying chronic inflammation constitute an important
metabolic problem that may lead to pathology, especially when the body is exposed to …

The intestinal mucosa must balance tolerance to commensal microbes and luminal antigens
with rapid detection of enteric pathogens in order to maintain homeostasis. This balance is …

Nucleotide-binding and oligomerization structural domain (NOD)-like receptors (NLRs) play
an important role in innate immunity as cytoplasmic pattern recognition receptors (PRRs) …

The emergence of combination antiretroviral therapy (cART) has greatly transformed the life
expectancy of people living with HIV (PWH). Today, over 76% of the individuals with HIV …