The detrusor smooth muscle is the main muscle component of the urinary bladder wall. Its
ability to contract over a large length interval and to relax determines the bladder function …

Introduction The normal bladder functions, storage and elimination of urine, are based on a
coordinated interplay of reciprocal contraction and relaxation of the bladder and the outflow …

The concept of a purinergic signaling system, using purine nucleotides and nucleosides as
extracellular messengers, was first proposed over 30 years ago. After a brief introduction …

The lower urinary tract constitutes a functional unit controlled by a complex interplay
between the central and peripheral nervous systems and local regulatory factors. In the …

The pharmacological treatment of urinary incontinence Page 1 BJU International (1999), 84,
923–947 REVIEW The pharmacological treatment of urinary incontinence K.-E …

Overactive bladder syndrome with and without urinary incontinence and related conditions,
signs, and disorders such as detrusor overactivity, neurogenic lower urinary tract …

Numerous studies have detailed age-related changes in the structure and function of the
bladder that may contribute to the high prevalence of overactive bladder (OAB) in the elderly …

The vascular supply to the human bladder is derived mainly from the superior and inferior
vesical arteries, the latter being directly connected to the internal iliac artery. Aging is …

Contraction of the bladder, voluntary or involuntary, involves stimulation of the muscarinic
receptors on the detrusor by acetylcholine, released from activated cholinergic nerves …

We investigated muscarinic receptors in the detrusor and mucosa of the human bladder
body. Radioligand-binding studies with [3 H] QNB were conducted using specimens …