Antimicrobial resistance is an old and silent pandemic. Resistant organisms emerge in
parallel with new antibiotics, leading to a major global public health crisis over time …

Tripartite efflux pumps and the related type 1 secretion systems (T1SSs) in Gram-negative
organisms are diverse in function, energization, and structural organization. They form …

Bacterial multidrug efflux pumps have come to prominence in human and veterinary
pathogenesis because they help bacteria protect themselves against the antimicrobials …

Drug resistance represents a great concern among people with cystic fibrosis (CF), due to
the recurrent and prolonged antibiotic therapy they should often undergo. Among Multi Drug …

Pseudomonas aeruginosa (P. aeruginosa) poses a grave clinical challenge due to its
multidrug resistance (MDR) phenotype, leading to severe and life-threatening infections …

The rise of multiresistant bacterial pathogens is currently one of the most critical threats to
global health, encouraging a better understanding of the evolution and spread of …

Tuberculosis (TB) is the leading cause of death from any bacterial infection, causing 1.5
million deaths worldwide each year. Due to the emergence of drug-resistant strains of …

The eradication of Pseudomonas aeruginosa in cystic fibrosis patients has become
continuously difficult due to its increased resistance to treatments. This study assessed the …

The discovery of bacterial efflux pumps significantly advanced our understanding of how
bacteria can resist cytotoxic compounds that they encounter. Within the structurally and …

Tripartite multidrug RND efflux systems made of an inner membrane transporter, an outer
membrane factor (OMF) and a periplasmic adaptor protein (PAP) form a canal to expel drugs …