In the setting of myocardial infarction (MI), ischemia reperfusion injury (IRI) occurs due to
occlusion (ischemia) and subsequent re-establishment of blood flow (reperfusion) of a …

Recent studies show that alloantibodies mediate a substantial proportion of graft-rejection
episodes, contributing to both early and late graft loss. Rejection that is caused by antibody …

Background The introduction of solid-phase immunoassay (SPI) technology for the detection
and characterization of human leukocyte antigen (HLA) antibodies in transplantation while …

Reports have associated non-HLA antibodies, specifically those against angiotensin II type-
1 receptor (AT1R), with antibody-mediated kidney graft rejection. However, association of …

Bronchiolitis obliterans syndrome (BOS), the clinical correlate of chronic rejection after lung
transplantation, is the leading obstacle to better long-term outcomes. We previously …

BACKGROUND: Bronchiolitis obliterans syndrome (BOS) is a major cause of morbidity and
mortality after lung transplantation (LTx). We sought to better understand the relationship …

Heat shock proteins (Hsps) can be found in two forms, intracellular and extracellular. The
intracellular Hsps are induced as a result of stress and have been found to be cytoprotective …

BACKGROUND: Herein we study the role of donor-specific antibodies (DSA) to mismatched
human leukocyte antigen (HLA) and antibodies (Abs) to the cardiac self-antigens myosin …

Autoimmune responses to vimentin occur after solid organ transplantation, but their
pathogenic effects are unclear. The aim of these studies was to investigate the effects of …

There is a growing body of data supporting a role for non-HLA antibodies in acute and
chronic rejection of solid organ transplants. While many of these non-HLA antigens remain …