Fungal diseases have been underestimated worldwide but constitute a substantial threat to
several plant and animal species as well as to public health. The increase in the global …

The global spread of COVID-19 has raised the importance of pharmaceutical drug
development as intractable and hot research. Developing new drug molecules to overcome …

Highlights•We provide a critical review of the current state of the activity cliff research.•We
comment on and integrate the opinions of experts working on activity cliffs.•The negative …

Recent research in drug discovery dealing with many faces difficulties, including
development of new drugs during disease outbreak and drug resistance due to rapidly …

Introduction: In multi-objective drug design, optimization gains importance, being upgraded
to a discipline that attracts its own research. Current strategies are broadly classified into …

Introduction Whereas in the past,(Q) SAR methods have been largely used to support the
design of new drugs, in the last few decades, there has been a new interest in its …

Introduction: Molecular topology (MT) has emerged in recent years as a powerful approach
for the in silico generation of new drugs. In the last decade, its application has become more …

Drug-induced liver injury (DILI) is a major cause of the withdrawal of pre-marketed drugs,
typically attributed to oxidative stress, mitochondrial damage, disrupted bile acid …

The integration of multiple virtual screening strategies facilitates the balance of
computational efficiency and prediction accuracy. In this study, we constructed an efficient …

Abstract Genetic programming (GP)(Koza, Genetic programming: a paradigm for genetically
breeding populations of computer programs to solve problems, Stanford University …