Exercise is a well-established tool to prevent and combat type 2 diabetes. Exercise improves
whole body metabolic health in people with type 2 diabetes, and adaptations to skeletal …

Recent data have suggested a key role for tumor necrosis factor (TNF)-α in the insulin
resistance of obesity and non-insulin-dependent diabetes mellitus (NIDDM). TNF-α …

Obesity is frequently associated with insulin resistance and abnormal glucose homeostasis.
Recent studies in animal models have indicated that TNF-alpha plays an important role in …

Short term high fat feeding in rats results specifically in hepatic fat accumulation and
provides a model of non-alcoholic fatty liver disease in which to study the mechanism of …

Obesity is accompanied by the activation of low-grade inflammatory activity in metabolically
relevant tissues. Studies have shown that obesity-associated insulin resistance results from …

THE principal substrate for the insulin and insulin-like growth factor-1 (IGF-1) receptors is the
cytoplasmic protein insulin-receptor substrate-1 (IRS-l/pplSS) 1–7. After tyrosine …

Insulin resistance is an important metabolic abnormality often associated with infections,
cancer, obesity, and especially non-insulin-dependent diabetes mellitus (NIDDM). We have …

The development of obesity and insulin resistance has been extensively studied in the last
decades, but the mechanisms underlying these alterations are still not completely …

The person who passes urine which is exceedingly sweet, cool, slightly viscid, turbid, and
resembling the juices of the sugarcane… suffers from glycosuria.… There are two types of …

Exercise increases the rate of glucose uptake into the contracting skeletal muscles. This
effect of exercise is similar to the action of insulin on glucose uptake, and the mechanism …