The global burden of neurodegenerative diseases underscores the urgent need for
innovative strategies to define new drug targets and disease-modifying factors. The …

Transition metal ions, such as copper, are indispensable components in the biological
system. Copper ions which primarily exist in two major oxidation states Cu (I) and Cu (II) play …

Amyotrophic lateral sclerosis (ALS) is a rare progressive motor neuron disease that, due to
its high complexity, still lacks effective treatments. Development of a new drug is a highly …

The cellular redox state, or balance between cellular oxidation and reduction reactions,
serves as a vital antioxidant defence system that is linked to all important cellular activities …

Amyotrophic lateral sclerosis/frontotemporal dementia (ALS/FTD) is a fatal
neurodegenerative disorder, and continued innovation is needed for improved …

Background Amyotrophic lateral sclerosis (ALS) is a serious neurodegenerative disorder
affecting nerve cells in the brain and spinal cord that is caused by mutations in the …

The impact of neurodegenerative illnesses on society is significant, but the mechanisms
leading to neuronal malfunction and death in these conditions remain largely unknown …

Amyotrophic lateral sclerosis-frontotemporal dementia spectrum disorder (ALS/FTD) is a
complex neurodegenerative disease; up to 10% of cases are familial, usually arising from …