Animal models have provided invaluable information in the pursuit of medical knowledge
and alleviation of human suffering. The foundations of our basic understanding of disease …

Medical and scientific advances are predicated on new knowledge that is robust and
reliable and that serves as a solid foundation on which further advances can be built. In …

Reproducible science requires transparent reporting. The ARRIVE guidelines (Animal
Research: Reporting of In Vivo Experiments) were originally developed in 2010 to improve …

Objective: Decades-old, common ICU practices including deep sedation, immobilization,
and limited family access are being challenged. We endeavoured to evaluate the …

Animal testing is used in pharmaceutical and industrial research to predict human toxicity,
and yet analysis suggests that animal models are poor predictors of drug safety in humans …

Here, we show that microfluidic organ-on-a-chip (organ chip) cell culture technology can be
used to create in vitro human orthotopic models of non-small-cell lung cancer (NSCLC) that …

We have developed a cancer model of gliomas in human cerebral organoids that allows
direct observation of tumor initiation as well as continuous microscopic observations. We …

Due to practical and ethical concerns associated with human experimentation, animal
models have been essential in cancer research. However, the average rate of successful …

A cornerstone of modern biomedical research is the use of mouse models to explore basic
pathophysiological mechanisms, evaluate new therapeutic approaches, and make go or no …

Establishment of an in vivo small animal model of human tumor and human immune system
interaction would enable preclinical investigations into the mechanisms underlying cancer …