Biocatalysis (the use of biological molecules or materials to catalyse chemical reactions) has
considerable potential. The use of biological molecules as catalysts enables new and more …

Phosphomevalonate kinase (PMK) is an important enzyme involved in the juvenile hormone
(JH) biosynthesis pathway that catalyzes the phosphorylation of mevalonate 5-phosphate …

Sanghuangporus baumii, a macrofungus belonging to the Hymenochaetaceae family, has
been widely used as a traditional medicine in Asia for centuries. Triterpenoids in S. baumii …

Mevalonate Kinase (MVK) catalyses the ATP-Mg2+ mediated phosphate transfer of
mevalonate to produce mevalonate 5-phosphate and is a key kinase in the mevalonate …

Isopentenyl phosphate kinase (IPK) catalyzes the Mg2+-ATP dependent phosphorylation
reactions to produce isopentenyl diphosphate, an important precursor in the synthesis of …

Mevalonate kinase is central to the isoprenoid biosynthesis pathway. Here, high-resolution
X-ray crystal structures of two mevalonate kinases are presented: a eukaryotic protein from …

Single-cell signaling is a complex and tightly regulated process essential for cellular
communication and coordination in multicellular organisms. At the heart of many signaling …

Mevalonate diphosphate decarboxylase (MDD) catalyses a crucial step of the mevalonate
pathway via Mg2+-ATP-dependent phosphorylation and decarboxylation reactions to …

The folate pathway is a recognized intervention point for treating parasitic and bacterial
infections in humans. However, the efficacy of treatments targeting dihydropteroate synthase …

Fosfomycin Resistance Kinase A (FomA) catalyzes the phosphorylation of fosfomycin, which
is an effective antibiotic for treating urinary tract infections. Understanding the chemical …