Genes and translated open reading frames (ORFs) that emerged de novo from previously
non-coding sequences provide species with opportunities for adaptation. When aberrantly …

Abstract “De novo” genes evolve from previously non-genic DNA. This strikes many of us as
remarkable, because it seems extraordinarily unlikely that random sequence would produce …

Human de novo genes can originate from neutral long non-coding RNA (lncRNA) loci and
are evolutionarily significant in general, yet how and why this all-or-nothing transition to …

Comparisons of genomes of different species are used to identify lineage-specific genes,
those genes that appear unique to one species or clade. Lineage-specific genes are often …

The testis is a peculiar tissue in many respects. It shows patterns of rapid gene evolution and
provides a hotspot for the origination of genetic novelties such as de novo genes …

The formation of new genes during evolution is an important motor of functional innovation,
but the rate at which new genes originate and the likelihood that they persist over longer …

Recent evidence demonstrates that novel protein-coding genes can arise de novo from non-
genic loci. This evolutionary innovation is thought to be facilitated by the pervasive …

Translation is the process by which ribosomes synthesize proteins. Ribosome profiling
recently revealed that many short sequences previously thought to be noncoding are …

High throughput RNA sequencing techniques have revealed that a large fraction of the
genome is transcribed into long non-coding RNAs (lncRNAs). Unlike canonical protein …

The noncoding genome plays an important role in de novo gene birth and in the emergence
of genetic novelty. Nevertheless, how noncoding sequences' properties could promote the …