Two of the most prevalent human viruses worldwide, herpes simplex virus type 1 and type 2
(HSV-1 and HSV-2, respectively), cause a variety of diseases, including cold sores, genital …

Introduction At the epicentre of the HIV epidemic in southern Africa, adolescent girls and
young women aged 15–24 contribute a disproportionate~ 30% of all new infections and …

Cluster Randomised Trials, Second Edition discusses the design, conduct, and analysis of
trials that randomise groups of individuals to different treatments. It explores the advantages …

Genital herpes is the main cause of genital ulcers worldwide; the prevalence of herpes
simplex virus (HSV) type 2 infections in the general population ranges from 10% to 60 …

Early studies that explored host–pathogen interactions assumed that infected individuals
within a population have equal chances of transmitting the infection to others. Subsequently …

HIV-1 infection typically results from the transmission of a single viral variant, the
transmitted/founder (T/F) virus. Studies of these HIV-1 variants provide critical information …

Background Most persons who are infected with human immunodeficiency virus type 1 (HIV-
1) are also infected with herpes simplex virus type 2 (HSV-2), which is frequently reactivated …

High plasma HIV-1 RNA concentrations are associated with an increased risk of HIV-1
transmission. Although plasma and genital HIV-1 RNA concentrations are correlated, no …

SUMMARY Herpes simplex virus 2 (HSV-2) is a DNA virus that is efficiently transmitted
through intimate genital tract contact and causes persistent infection that cannot be …

Materials and Methods The PubMed, Embase and AIDSearch databases were searched on
January 8, 2007 using the following search terms:(HIV or human immunodeficiency virus) …