Design and application of fluorescent probes to detect cellular physical microenvironments
The microenvironment is indispensable for functionality of various biomacromolecules,
subcellular compartments, living cells, and organisms. In particular, physical properties …
subcellular compartments, living cells, and organisms. In particular, physical properties …
Molecular rotors: fluorescent sensors for microviscosity and conformation of biomolecules
M Paez‐Perez, MK Kuimova - Angewandte Chemie, 2024 - Wiley Online Library
The viscosity and crowding of biological environment are considered vital for the correct
cellular function, and alterations in these parameters are known to underly a number of …
cellular function, and alterations in these parameters are known to underly a number of …
Molecular Machines For The Control Of Transmembrane Transport
TG Johnson, MJ Langton - Journal of the American Chemical …, 2023 - ACS Publications
Nature embeds some of its molecular machinery, including ion pumps, within lipid bilayer
membranes. This has inspired chemists to attempt to develop synthetic analogues to exploit …
membranes. This has inspired chemists to attempt to develop synthetic analogues to exploit …
Dual ratiometric fluorescence monitoring of mechanical polymer chain stretching and subsequent strain-Induced crystallization
Tracking the behavior of mechanochromic molecules provides valuable insights into force
transmission and associated microstructural changes in soft materials under load. Herein …
transmission and associated microstructural changes in soft materials under load. Herein …
Fluorogenic In Situ Thioacetalization: Expanding the Chemical Space of Fluorescent Probes, Including Unorthodox, Bifurcated, and Mechanosensitive Chalcogen …
Progress with fluorescent flippers, small-molecule probes to image membrane tension in
living systems, has been limited by the effort needed to synthesize the twisted push–pull …
living systems, has been limited by the effort needed to synthesize the twisted push–pull …
Core‐Alkynylated Fluorescent Flippers: Altered Ultrafast Photophysics to Track Thick Membranes
KKP Pamungkas, I Fureraj, L Assies… - Angewandte Chemie …, 2024 - Wiley Online Library
Fluorescent flippers have been introduced as small‐molecule probes to image membrane
tension in living systems. This study describes the design, synthesis, spectroscopic and …
tension in living systems. This study describes the design, synthesis, spectroscopic and …
Push–pull fluorescent dyes with trifluoroacetyl acceptor for high-fidelity sensing of polarity and heterogeneity of lipid droplets
N Aknine, AS Klymchenko - Analytical Chemistry, 2024 - ACS Publications
Imaging and sensing of lipid droplets (LDs) attracted significant attention due to growing
evidence for their important role in cell life. Solvatochromic dyes are promising tools to probe …
evidence for their important role in cell life. Solvatochromic dyes are promising tools to probe …
Recent development of advanced fluorescent molecular probes for organelle-targeted cell imaging
S Lu, Z Dai, Y Cui, DM Kong - Biosensors, 2023 - mdpi.com
Fluorescent molecular probes are very powerful tools that have been generally applied in
cell imaging in the research fields of biology, pathology, pharmacology, biochemistry, and …
cell imaging in the research fields of biology, pathology, pharmacology, biochemistry, and …
Excitation-Wavelength-Dependent Photophysics of a Torsionally Disordered Push–Pull Dye
I Fureraj, J Wega, E Balanikas… - The Journal of …, 2024 - ACS Publications
The torsional disorder of conjugated dyes in the electronic ground state can lead to
inhomogeneous broadening of the S1← S0 absorption band, allowing for the selective …
inhomogeneous broadening of the S1← S0 absorption band, allowing for the selective …
Tensing Flipper: Photosensitized Manipulation of Membrane Tension, Lipid Phase Separation, and Raft Protein Sorting in Biological Membranes
The lateral organization of proteins and lipids in the plasma membrane is fundamental to
regulating a wide range of cellular processes. Compartmentalized ordered membrane …
regulating a wide range of cellular processes. Compartmentalized ordered membrane …