Microglia are mononuclear phagocytes of mesodermal origin that migrate to the central
nervous system (CNS) during the early stages of embryonic development. After colonizing …

There is a huge need for novel therapeutic and preventative approaches to Alzheimer's
disease (AD) and neuroinflammation seems to be one of the most fascinating solutions. The …

Brain inflammation generally accompanies and accelerates neurodegeneration. Here we
report a microglial mechanism in which polyglutamine binding protein 1 (PQBP1) senses …

The current pandemic was caused by the severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2). The quarantine period during corona virus disease 19 (COVID-19) outbreak …

Diabetes mellitus is a heterogeneous chronic metabolic disorder characterized by the
presence of hyperglycemia, commonly preceded by a prediabetic state. The excess of blood …

To accommodate the changing needs of the developing brain, microglia must undergo
substantial morphological, phenotypic, and functional reprogramming. Here, we examined …

In response to various types of environmental and cellular stress, microglia rapidly activate
and exhibit either pro-or anti-inflammatory phenotypes to maintain tissue homeostasis …

Microglia are universal sensors of alterations in CNS physiology. These cells integrate
complex molecular signals and undergo comprehensive phenotypical remodeling to adapt …

Under conditions leading to aging and metabolic syndrome, the hypothalamus atypically
undergoes proinflammatory signaling activation leading to a chronic and stable background …

Obesity and aging are two important epidemic factors for metabolic syndrome and many
other health issues, which contribute to devastating diseases such as cardiovascular …