Cellular senescence entails a permanent proliferative arrest, coupled to multiple phenotypic
changes. Among these changes is the release of numerous biologically active molecules …

Reactive oxygen species (ROS) are metabolic byproducts that are necessary for
physiological function but can be toxic at high levels. Levels of these oxidative stressors …

Aging is the greatest risk factor for a multitude of diseases including cardiovascular disease,
neurodegeneration and cancer. Despite decades of research dedicated to understanding …

For several decades, understanding ageing and the processes that limit lifespan have
challenged biologists. Thirty years ago, the biology of ageing gained unprecedented …

Among other mechanisms, oxidative stress has been postulated to play an important role in
the rate of ageing. Oxidative damage contributes to the hallmarks of ageing and essential …

Research on the role of reactive oxygen species (ROS) in the aging process has advanced
significantly over the last two decades. In light of recent findings, ROS takes part in the aging …

Oxidative stress refers to elevated intracellular levels of reactive oxygen species (ROS) that
cause damage to lipids, proteins and DNA. Oxidative stress has been linked to a myriad of …

Aging is a major risk factor for a number of chronic diseases, including neurodegenerative
and cerebrovascular disorders. Aging processes have therefore been discussed as potential …

Vitamin E is an essential nutrient that was discovered in the 1920s. Many of the
physiological functions of vitamin E, including its antioxidative effects, have been studied for …

Aging is characterized by a progressive loss of physiological integrity, leading to impaired
function and increased vulnerability to death. This deterioration is the primary risk factor for …