Recombinant spider silk: promises and bottlenecks

M Ramezaniaghdam, ND Nahdi… - Frontiers in Bioengineering …, 2022 - frontiersin.org
Spider silk threads have exceptional mechanical properties such as toughness, elasticity
and low density, which reach maximum values compared to other fibre materials. They are …

Prospects of using chitosan-based biopolymers in the treatment of peripheral nerve injuries

M Zhang, H An, F Zhang, H Jiang, T Wan… - International Journal of …, 2023 - mdpi.com
Peripheral nerve injuries are common neurological disorders, and the available treatment
options, such as conservative management and surgical repair, often yield limited results …

Development and in vitro differentiation of Schwann cells

SJ Hörner, N Couturier, DC Gueiber, M Hafner… - Cells, 2022 - mdpi.com
Schwann cells are glial cells of the peripheral nervous system. They exist in several
subtypes and perform a variety of functions in nerves. Their derivation and culture in vitro are …

Silk‐in‐Silk Nerve Guidance Conduits Enhance Regeneration in a Rat Sciatic Nerve Injury Model

L Semmler, A Naghilou, F Millesi, S Wolf… - Advanced …, 2023 - Wiley Online Library
Advanced nerve guidance conduits can provide an off‐the‐shelf alternative to autografts for
the rehabilitation of segmental peripheral nerve injuries. In this study, the excellent …

Factors influencing properties of spider silk coatings and their interactions within a biological environment

VT Trossmann, S Lentz, T Scheibel - Journal of Functional Biomaterials, 2023 - mdpi.com
Biomaterials are an indispensable part of biomedical research. However, although many
materials display suitable application-specific properties, they provide only poor …

Designed multifunctional spider silk enabled by genetically encoded click chemistry

B Jiang, SY Tan, S Fang, X Feng… - Advanced Functional …, 2023 - Wiley Online Library
Spider silk is recognized for its exceptional mechanical properties and biocompatibility,
making it a versatile platform for developing functional materials. In this study, a modular …

[HTML][HTML] The properties of native Trichonephila dragline silk and its biomedical applications

F Bergmann, S Stadlmayr, F Millesi, M Zeitlinger… - Biomaterials …, 2022 - Elsevier
Spider silk has fascinated mankind for millennia, but it is only in recent decades that
scientific research has begun to unravel all its characteristics and applications. The …

Systematic comparison of commercial hydrogels revealed that a synergy of laminin and strain-stiffening promotes directed migration of neural cells

F Millesi, S Mero, L Semmler, A Rad… - … Applied Materials & …, 2023 - ACS Publications
Hydrogels have shown potential in replacing damaged nerve tissue, but the ideal hydrogel
is yet to be found. In this study, various commercially available hydrogels were compared …

Spidroin‐Based Biomaterials in Tissue Engineering: General Approaches and Potential Stem Cell Therapies

Q Zhang, M Li, W Hu, X Wang, J Hu - Stem Cells International, 2021 - Wiley Online Library
Spider silks are increasingly gaining interest for potential use as biomaterials in tissue
engineering and biomedical applications. Owing to their facile and versatile processability in …

Comparative analysis of various spider silks in regard to nerve regeneration: material properties and Schwann cell response

S Stadlmayr, K Peter, F Millesi, A Rad… - Advanced …, 2024 - Wiley Online Library
Peripheral nerve reconstruction through the employment of nerve guidance conduits with
Trichonephila dragline silk as a luminal filling has emerged as an outstanding preclinical …